2012 Fiscal Year Final Research Report
Effect of Changes in Central Hemodynamics on the RespiratoryChemorelfex Feedback System Controlling Ventilation in Humans.
| Project/Area Number |
22500617
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Sports science
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| Research Institution | Morinomiya University of Medical Sciences |
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Principal Investigator |
MIYAMOTO Tadayoshi 森ノ宮医療大学, 大学院・保健医療学研究科, 教授 (40294136)
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| Co-Investigator(Kenkyū-buntansha) |
OGOH Shigehiko 東洋大学, 理工学部, 教授 (80553841)
NAKAHARA Hidehiro 森ノ宮医療大学, 大学院・保健医療学研究科, 講師 (90514000)
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| Project Period (FY) |
2010 – 2012
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| Keywords | システム生理学 / 運動 / 呼吸調節 / 負帰還系 / 換気量 / 化学受容器反射 / 呼吸 |
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| Research Abstract |
Although previous findings indicate that central blood volume (CBV) shift influences the respiratory regulation, the major regulatory mechanisms in the respiratory chemoreflex system which determine the operating arterial partial pressure of CO2 and minute ventilation responses to changes in CBV remain unclear. Using respiratory equilibrium diagram analysis, we evaluated the effect of CBV shift on the respiratory chemoreflex system divided into two subsystems: a controller (controlling system) and a plant (controlled system). Our findings first provide that CBV shift are related to the alteration in the properties of both controller and plant subsystems, and thus alter the operation mechanism of respiratory regulation under CBV shift. The equilibrium diagram analysis clearly indicates that resetting of the controller, rather than the plant, contributes predominantly to shift in the operating point under CBV shift.The respiratory controller resetting and/or plant dysfunction induced by CBV shift may be contributing to ventilatory abnormalities in CHF.
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Research Products
(18 results)
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[Presentation] The central chemoreflex activation induces sympathoexcitation and resets the arterial baroreflex without compromising its pressure stabilizing function.2012
Author(s)
Saku K, Hosokawa K, Sakamoto T Onitsuka K, Sakamoto K, Tobushi T, Fujino T, Kakino T, Ikeda M, Miyamoto T, Ide T, Sunagawa K.
Organizer
AMERICAN HEART ASSOCIATION CONFERENCE,Washington
Place of Presentation
D. C-USA
Year and Date
20120919-22
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