2012 Fiscal Year Final Research Report
Oxidative stress-regulated glucose transport in skeletal muscle from training and cast immobilization in mice
| Project/Area Number |
22500618
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Sports science
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| Research Institution | Fukuoka University |
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Principal Investigator |
HIGAKI Yasuki 福岡大学, スポーツ科学部, 教授 (10228702)
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| Co-Investigator(Kenkyū-buntansha) |
TANAKA Hiroaki 福岡大学, スポーツ科学部, 教授 (00078544)
KIYONAGA Akira 福岡大学, スポーツ科学部, 教授 (70177955)
TOBINA Takuro 長崎県立大学, 看護栄養学部, 講師 (60509678)
SUDO Mizuki 福岡大学, 身体活動研究所, ポストドクター (10585186)
ANDO Soichi 福岡大学, スポーツ科学部, 助教 (50535630)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 一酸化窒素合成酵素 |
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| Research Abstract |
Rat skeletal muscle expresses NO synthase and that activity varies among several muscles. We hypothesized that NO as one of reactive oxygen intermediates modulates skeletal muscle glucose transport. First, we tried to make available methods for the model of training and inactivity in mice. Next, to determine if an epigenetic modification of NOS gene involves in mediating glucose transport in skeletal muscle, methylation of cytosines at CpG sites in promoter region of NOS gene was analyzed in these samples. Our results demonstrate that DNA methylation of the NOS promoter may be involved in the regulation of glucose metabolism in skeletal muscle.
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