2012 Fiscal Year Final Research Report
Understanding of the mechanisms underlying the association between sarcopenia and GSK3‐β signaling.
| Project/Area Number |
22500658
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Applied health science
|
|---|
| Research Institution | The University of Tokyo |
|---|
Principal Investigator |
WAGATSUMA Akira 東京大学, 大学院・情報理工学系研究科, 学術支援専門職員 (00347121)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Keywords | サルコペニア / サテライト細胞 / 老化 |
|---|
| Research Abstract |
To elucidate the possible role of glycogen synthase kinase 3β (GSK-3β) in sarcopenia, we investigated the relationship between its phosphorylation levels and the differentiation potential of satellite cells in vitro. The level of phosphorylation of GSK-3β was slightly decreased in satellite cells derived from old mice compared with adult mice. No significant difference in differentiation potential was observed between old and adult satellite cells, suggesting that satellite cells retain sufficient capacity to myogenic differentiation, irrespective of ageing. Additionally, we investigated whether inhibition of GSK-3β activity by lithium promote cell differentiation. This treatment almost equally accelerated myotube formation in both old and adult satellite cells. Taken together, inhibition of GSK-3β may contribute toattenuate age-related decline in skeletal muscle mass.
|
