2012 Fiscal Year Final Research Report
A new predicting method and health guidance for the progression of subclinical atherosclerosis using new lifestyle-related serum markers.
| Project/Area Number |
22500663
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Applied health science
|
|---|
| Research Institution | Osaka University |
|---|
Principal Investigator |
NISHIDA Makoto 大阪大学, 保健センター, 准教授 (00379273)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Keywords | 動脈硬化 / 危険因子 / 生活習慣 / 酸化ストレス / アポ蛋白 |
|---|
| Research Abstract |
New serum markers which may indicate carotid atherosclerosis were evaluated with life-style in annual health checkup. ApoB48, a marker for lipids absorbed from intestine, did not correlate with atherosclerosis in all subjects, but significantly correlated in non-obese subjects. It shows apoB48 can be an useful marker detecting atherosclerosis in non-obese subjects. Other new markers including oxidative stress did not associate with progression of atherosclerosis, but with risk factors. Notably, smoking significantly associated progression of atherosclerosis even in a short period. It emphasizes the importance to stop smoking early.
|
