Study of anti-metabolic syndrome effects of cholesteryl ester-n3 PUFA targeting for liver energy metabolism alteration in non-alcoholic steatohepatitis rats.

2012 Fiscal Year Final Research Report

• Project/Area Number: 22500665
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Applied health science
• Research Institution: Okayama University
• Principal Investigator: TAKAYAMA Fusako 岡山大学, 大学院・医歯薬学総合研究科, 准教授 (10236367)
• Co-Investigator(Kenkyū-buntansha): OKADA Shigeru 岡山大学, 大学院・医歯薬学総合研究科, 特命教授, 名誉教授 (20033201)
• Research Collaborator: SUGIMOTO Shiho 岡山大学, 大学院・医歯薬学総合研究科, 博士前期課程・大学院生 ; MANKURA Mitsumasa 池田糖化工業株式会社, 理事 ; SATO Fumi 池田糖化工業株式会社, 研究室, 研究員 ; TOYODA Hiroshi 岡山協立病院, 病理部, 部長 ; WATANABE Ritsuko 岡山協立病院, 病理部, 主任 ; OKADA Shigeru 岡山大学, 大学院・医歯薬学総合研究科, 特命教授, 名誉教授
• Project Period (FY): 2010 – 2012
• Keywords: NASH / 低酸素 / エネルギー代謝 / ミトコンドリア / 酸化ストレス / 炎症 / 鉄 / n-3 PUFA

Research Abstract

This study showed that DHA cholesteryl ester and EPA one were useful industrially, as both exerted higher effects to retard the NASH progress approximately 10 times than the respective ethyl ester. By evaluation system to reproduce NASH aggravation by choline deficient high fat diets and besides recurrent intermittent oxygen deficiency stress, it was exhibited that the efficacies resulted from relieving the decreased erythrocyte deformability and the persistent oxidative stress-inflammation.

Research Products

• [Journal Article] Effects of squalene/squalane on dopamine levels, antioxidant enzyme activity, and fatty acid composition in the striatum of Parkinson's disease mouse model. (2013)
  • Author(s): Kabuto H, Yamanushi T, Janjua N, Takayama F, Mankura M
  • Journal Title: J Oleo Sci Volume: 62(1) Pages: 21-28
  • Peer Reviewed
• [Journal Article] Anti-oxidative and anti-inflammatory effects of spirulina on rat model of non-alcoholic steatohepatitis. (2012)
  • Author(s): Pak W, Takayama F, Mine M, Nakamoto K, Kodo Y, Mankura M, Egashira T, Kawasaki H, Mori A
  • Journal Title: J Clin Biochem Nutr Volume: 51(3) Pages: 227-234
  • Peer Reviewed
• [Journal Article] Do Cholinergic Nerves Innervating Rat Mesenteric Arteries Regulate Vascular Tone? (2012)
  • Author(s): Panot T, Takatori S, Sun P, Zamami Y
  • Journal Title: Am J Physiol Regul Integr Comp Physiol Volume: 303 Pages: R1147- 1156
  • Peer Reviewed
• [Journal Article] NASHをターゲットとする食品の開発 (2011)
  • Author(s): 高山房子, 中本賀寿夫, 峰麻奈加, 杉本志保, 白穎, 江頭亨, 川崎博巳, 黄堂泰昌, 万倉三正, 岡田茂, 森昭胤
  • Journal Title: 臨床化学 Volume: 40 Pages: 333-340
  • Peer Reviewed
• [Journal Article] Structure-based design, synthesis, and nonalcoholic steatohepatitis (NASH)-preventive effect of phenylpropanoic acid peroxisome proliferator-activated receptor (PPAR) a-selective agonists (2011)
  • Author(s): Ban S, Kasuga J, Nakagome I, Nobusada H, Takayama F,(他2名)
  • Journal Title: Bioorg Med Chem Pages: 193183-193191
  • Peer Reviewed
• [Journal Article] DHA 製品の開発と機能性評価. (2010)
  • Author(s): 万倉三正, 西岡巧志, 加太英明(他5名)
  • Journal Title: ジャパンフードサイエンス Volume: 49 Pages: 45-52
• [Journal Article] Effects of docosahexaenoic acid in an experimental rat model of nonalcoholic steatohepatitis. (2010)
  • Author(s): Takayama F, Nakamoto N, Totani N, (他4名)
  • Journal Title: J Oleo Sci Volume: 59 Pages: 407-414
  • Peer Reviewed
• [Remarks]
  • URL: http:/www.okayama-u.ac.jp/user/therahl/index.html