2012 Fiscal Year Final Research Report
Eicosapentaenoic acid supplementation on baroreflex sensitivity in patients with coronary artery disease.
| Project/Area Number |
22500668
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied health science
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| Research Institution | Oita University |
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Principal Investigator |
YUFU Kunio 大分大学, 医学部, 助教 (00437930)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 心臓自律神経 / 魚油 / baroreflex sensitivity / Eicosapentaenoic acid / 心血管イベント |
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| Research Abstract |
(1)BRS value could predict cardio- and cerebrovascular events in patients with type 2 diabetes. Therapeutic preventive strategies targeting the improvement of BRS should be considered in this population. (2)Depressed BRS value could predict cardiac cerebrovascular events especially in female patients with type 2 diabetes. Once diabetic, a female who developed an impaired BRS had a worse prognosis than similar male. Intensive management and/or therapy might be needed in this population. (3)Dietary EPA supplementation might increase serum levels of EPA and BRS value in patients with coronary artery disease. These effects might be one of reason why EPA had been associated with a reduced incidence of adverse cardiovascular events in patients with coronary artery disease.
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[Journal Article] Baroreflex sensitivity predicts cardiovascular events in patients with type 2 diabetes mellitus without structural heart disease2010
Author(s)
Okada N,Takahashi N,Yufu K,Murozono Y,Wakisaka O,Shinohara T,Anan F, Nakagawa M,Hara M,Saikawa T,Yoshimatsu H
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Journal Title
Circ J
Volume: 74(7)
Pages: 1379-1383
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