2012 Fiscal Year Final Research Report

Investigation for mechanisms of "resistance to lipid" in skeletal muscle

Research Project

Project/Area Number	22500676
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Applied health science
Research Institution	Juntendo University
Principal Investigator	KANAZAWA Akio 順天堂大学, 医学部, 准教授 (30407259)
Co-Investigator(Kenkyū-buntansha)	TAMURA Yoshifumi 順天堂大学, 医学部, 准教授 (80420834)
Project Period (FY)	2010 – 2012
Keywords	インスリン抵抗性 / 骨格筋細胞内脂質
Research Abstract	The accumulation of intramyocellular lipid (IMCL) is regarded to be a cause of insulin resistance. On the other hand, increased accumulation of IMCL is also observed in insulin sensitive subjects (resistance to lipids). Thus, we aimed to clarify the mechanisms of the phenomenon. The IMCL levels were measured by 1H-magnetic resonance spectroscopy (MRS) and peripheral insulin sensitivity (GIR) was evaluated by clamp study. Muscle biopsy sample was obtained from vastus lateralis. Resistance to lipids is associated with increased expression level of lipid oxidation and uptake genes in skeletal muscle. These gene expressions may intermediate IMCL accumulation and insulin sensitivity.

(1 results)