2012 Fiscal Year Final Research Report
Anti-aging effects of melatonin on age-related deficits in learningand memory
| Project/Area Number |
22500677
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied health science
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| Research Institution | Sophia University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HATTORI Atsuhiko 東京医科歯科大学, 教養部, 教授 (70183910)
OKADA Takashi 上智大学, 総合人間科学部, 教授 (00242082)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 老化 / 加齢 / メラトニン / 記憶 |
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| Research Abstract |
We examined the effects of melatonin on age-related deficits in learning andmemory in the mice which were given drinking water with/without melatonin for 8 month from 11months old (middle age) to 19 months old (old age). We also examined the accumulation of8-hydroxy-2'-deoxyguanosine (8-OHdG) in the brain of these mice as an index of oxidative stress. Themelatonin treated old mice showed improved memory and reduced accumulation of 8-OHdG whencompared with untreated old mice. These data suggested the possibility that melatonin attenuatesage-related deficits in learning and memory through its anti-oxidative action.
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