2012 Fiscal Year Final Research Report
Examination of the effect of eccentric exercise on fast-twitch muscle fiber metabolism over a lifespan
| Project/Area Number |
22500679
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied health science
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| Research Institution | Toho University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Keywords | 加齢 / 老化 |
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| Research Abstract |
To examine the effects of eccentric exercise (downhill walking) on the decline of muscular function with age, animals (rats)performed low intensity downhill walking for 2 years. As a result, the exercise reduced mitochondrial oxidative stress, which has been shown to have a negative impact on muscular function, and slowed the decline in muscular metabolism. Particularly, the effect of the exercise on the development of oxidative stress with age was clear in fast-twitch muscle. These results suggest that eccentric exercise can help to prevent a decline in muscular function with age.
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