• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2012 Fiscal Year Final Research Report

Protective effect of hydrogen molecule learning and memory function in oxidative stress induced mice.

Research Project

  • PDF
Project/Area Number 22500680
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Applied health science
Research InstitutionNippon Medical School

Principal Investigator

NISHIMAKI Kiyomi  日本医科大学, 老人病研究所, マネージメントサポートスタッフ (00465345)

Project Period (FY) 2010 – 2012
Keywords老化・加齢 / 酸化ストレス / 水素
Research Abstract

Accumulation of oxidative stress associated with aging is one of causative factors in the pathogenesis of major neurodegenerative diseases including Alzheimer’ and Parkinson diseases (AD and PD). Hydrogen molecules(H2) are superior antioxidants, selectively reduced the hydroxyl radical,the most cytotoxic Ros, without affecting the other oxygen-derived free radicals. In this study, we investigated the effect of an antioxidant, hydrogen molecule (H2), using DAL mice as Alzheimer's disease animal model. We showed that the consumption of molecular hydrogen reduces brainoxidative stress levels and inhibit the cognitive decline and neurodegeneration.

  • Research Products

    (17 results)

All 2013 2012 2011 2010 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (14 results) Remarks (1 results)

  • [Journal Article] Taurine ameliorates impaired mitochondrial function and prevents stroke-like episodes in patients with MELAS2012

    • Author(s)
      Rikimaru N, Ohsawa Y, Wolf AM, Nishimaki K, Ichimiya H, Kamimura N, Nishimatsu S, Ohta S, Sunada Y
    • Journal Title

      Intern Med

      Volume: 51(24) Pages: 3351-3357

    • DOI

      DOI:10.2169/inte rnalmedicine.51.7529

    • Peer Reviewed
  • [Journal Article] Molecular Hydrogen Improves Obesity and Diabetes by Inducing Hepatic FGF21 and Stimulating Energy Metabolism in db/db Mice2011

    • Author(s)
      Kamimura N, Nishimaki K, Ohsawa I, Ohta S
    • Journal Title

      Obesity

      Volume: 19(7) Pages: 1396-1403

    • DOI

      DOI:10.1038/oby.2011.6.

    • Peer Reviewed
  • [Presentation] Consumption of hydrogen water is effective for the progression of Alzheimer's disease. AD/PD20132013

    • Author(s)
      Kiyomi Nishimaki
    • Organizer
      The 11^<th> International Conference On Alzheimer's & Parkinson's Diseases
    • Place of Presentation
      Florence, Italy
    • Year and Date
      20130306-10
  • [Presentation] Hydrogen Molecule improves leaning and memory function in mitochondrial oxidative stress-induced Alzheimer model mice. AD/PD20132013

    • Author(s)
      Takashi Yokota
    • Organizer
      The 11^<th> International Conference On Alzheimer's & Parkinson's Diseases
    • Place of Presentation
      Florence, Italy
    • Year and Date
      20130306-10
  • [Presentation] APP transgenic mice with oxidative stress. AD/PD20132013

    • Author(s)
      Naomi Kamimura
    • Organizer
      The 11^<th> International Conference On Alzheimer's & Parkinson's Diseases
    • Place of Presentation
      Florence, Italy
    • Year and Date
      20130306-10
  • [Presentation] Effects of intravenous transplantation of bone marrow mononuclear cell on Alzheimer's disease mouse models.AD/PD20132013

    • Author(s)
      Takuya Kanamaru
    • Organizer
      The 11^<th> International Conference On Alzheimer's & Parkinson's Diseases
    • Place of Presentation
      Florence, Italy
    • Year and Date
      20130306-10
  • [Presentation] ミトコンドリアアルデヒド脱水素酵素2活性欠損マウス(DAL101マウス)に対する骨髄単核球移植の認知機能改善効果2012

    • Author(s)
      金丸拓也
    • Organizer
      第12回日本ミトコンドリア学会年会
    • Place of Presentation
      つくば
    • Year and Date
      20121219-21
  • [Presentation] Optical recording of oxidative stress in live mice2012

    • Author(s)
      Wolf Alexander M
    • Organizer
      第12回日本ミコンドリア学会年会
    • Place of Presentation
      つくば
    • Year and Date
      20121219-21
  • [Presentation] ヒト変異APP高発現マウスと酸化ストレス亢進マウスとの掛け合わせマウスの解析2012

    • Author(s)
      上村尚美
    • Organizer
      第35回日本分子生物学会
    • Place of Presentation
      福岡
    • Year and Date
      20121211-14
  • [Presentation] アルツハイマーモデルマウスに対する他家骨髄単核球投与の認知機能改善効果2012

    • Author(s)
      金丸拓也
    • Organizer
      第35回日本分子生物学会
    • Place of Presentation
      福岡
    • Year and Date
      20121211-14
  • [Presentation] Optical recording of oxidative stress in live Mice2012

    • Author(s)
      Wolf Alexander M
    • Organizer
      第35回日本分子生物学会
    • Place of Presentation
      福岡
    • Year and Date
      20121211-14
  • [Presentation] Transgenic mice expressing roGFP have potential to estimate oxidative stress in vivo2011

    • Author(s)
      Kiyomi Nishimaki
    • Organizer
      第34回日本分子生物学会
    • Place of Presentation
      横浜
    • Year and Date
      20111213-16
  • [Presentation] IN vivo measurements of skin oxidative stress using mice expressing redox-sensitive GFP2011

    • Author(s)
      Alexander Wolf
    • Organizer
      5th SFRR-Asia, 8th ASMRM, 11th J-mit,2011Symposium
    • Place of Presentation
      Kagoshima
    • Year and Date
      20110831-0904
  • [Presentation] Transgenic mice expressing the redox-sensitive green fluorescent protein2011

    • Author(s)
      Kiyomi Nishimaki
    • Organizer
      5th SFRR-Asia, 8th ASMRM, 11th J-mit, 2011 Symposium
    • Place of Presentation
      Kagoshima
    • Year and Date
      20110831-0904
  • [Presentation] Preventive effect of hydrogen-dissolved water on age-dependent decline of learning and memory in Alzheimer model mice2011

    • Author(s)
      Kiyomi Nishimaki
    • Organizer
      The eighth European Meeting on Mitochondrial Pathology (Euromit 8)
    • Place of Presentation
      スペイン
    • Year and Date
      20110620-23
  • [Presentation] Consumption of hydrogen water prevents the age-dependent impairment in learning and memory tasks in Alzheimer model mice2010

    • Author(s)
      Kiyomi Nishimaki
    • Organizer
      7th ASMRM (Asian symposium of Mitochondrial Research andMedicine) and 10th J-mit (Japanese Mitochondrial Research and Medicine)
    • Place of Presentation
      福岡
    • Year and Date
      20101216-18
  • [Remarks]

    • URL

      http://home.nms.ac.jp/ig/saiboseibutsu/gyoseki.html

URL: 

Published: 2014-08-29   Modified: 2015-10-20  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi