2012 Fiscal Year Final Research Report
Novel role of glucose receptor and orexin neuron as sensor of cerebral ischemia
| Project/Area Number |
22500683
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied health science
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| Research Institution | Kobe Gakuin University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NAKAMOTO Kazuo 神戸学院大学, 薬学部, 講師 (30432636)
FUJITA Wakako (HAMABE Wakako) 神戸学院大学, 薬学部, 講師 (30382328)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 生活習慣病 / orexin 神経 / グルコース受容体 / 脳卒中 / 血糖値 |
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| Research Abstract |
In this study, we determined the effects of intra-hypothalamic administration of orexin-A on the development of post-ischemic glucose intolerance, including changes in insulin signaling and ischemic neuronal damage.In conclusion, regulation of post-ischemic glucose intolerance by intra-hypothalamic administration of orexin-A significantly suppressed cerebral ischemic neuronal damage. These findings provide some insight into the therapeutic effectiveness of the use of this endogenous neuropeptide. These results from the present study may be helpful for the development of new agents and strategies for clinical treatment of cerebral stroke.
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