2012 Fiscal Year Final Research Report
Functional change in brain reward system is associated with fat preference and hyperphagia in diet-induced obesity
| Project/Area Number |
22500685
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied health science
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| Research Institution | Fukuoka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MINE Kazunori 福岡大学, 薬学部, 教授 (60150421)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 肥満 / 高脂肪食 / 食行動 / 脳内報酬系 / GABA / ドパミン |
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| Research Abstract |
Diet-induced obese mice exhibit higher preference for fat in a diet. This behavior change in mice is associated with decrease in the excitation of GABA neurons and decrease in D2 receptor-mediated inhibition of dopamine neurons in the reward-related brain area. We suggest that the acceleration of dopaminergic function in the brain reward system contributes to high fat preference in diet-induced obesity.
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[Journal Article] Effects of the serotonin 1A, 2A, 2C, 3A, and 3B and serotonin transporter gene polymorphisms on the occurrence of paroxetine discontinuation syndrome.2010
Author(s)
Murata Y, Kobayashi D, Imuta N,Haraguchi K, Ieiri I, Nishimura R,Koyama S, Mine K.
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Journal Title
J Clin Psychopharmacol
Volume: 30
Pages: 11-17
Peer Reviewed
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