2012 Fiscal Year Final Research Report

Effects of the area-specific cultivar extracts on the activation of thermo-sensitive ion channels

Research Project

Project/Area Number	22500732
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Eating habits, studies on eating habits
Research Institution	University of Shizuoka
Principal Investigator	MORITA Akihito 静岡県立大学, 食品栄養科学部, 助教 (40239653)
Project Period (FY)	2010 – 2012
Keywords	食素材 / イオンチャネル / 肥満 / 脂肪肝
Research Abstract	Effects of cultivars in the Shizuoka area on the thermo-sensitive ion channels were investigated. The activity of thermo-sensitive TRPV1 or TRPA1 was measured after the addition of solvent extracts from wheat flour, Japanese pepper, onion, strawberry, scallion bakers garlic, and welsh onion. Although some extracts activate TRPV1 and/or TRPA1 channels, the components that activate these channels strongly, have not beenisolated. In order to investigate the preventive effects of these channel activatingcomponents on the fatty liver, acute alcoholic fatty liver model was created by the administration of ethanol into mice.