2012 Fiscal Year Final Research Report
Fundamental research for the countermeasure against viral infectious disease by oral intake of ・-carotene
| Project/Area Number |
22500761
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | The University of Tokushima |
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Principal Investigator |
YAMANISHI Rintaro 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 准教授 (30253206)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 健康と食生活 / 食品免疫学 |
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| Research Abstract |
The intracellular level of reduced glutathione (GSH) in immune cells has influences on the immunity. In the present study, we focused on the effect of carotenoids such as ・-carotene on the properties of glutamate-cysteine-ligase (GCL) which is involved in GSH synthesis. Experiments with a GCL specific inhibitor, a translation inhibitor, and a transcription inhibitor revealed that certain caroteonids including ・-carotene induce de novosynthesis of GCL accompanied with the up-regulation of transcription, which resulted in the enhancement of the intracellular GSH level.
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