A study on Anti-H. pylori actions of pomegranate juice

2012 Fiscal Year Final Research Report

• Project/Area Number: 22500775
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Eating habits, studies on eating habits
• Research Institution: Tokai University
• Principal Investigator: MATSUSHIMA Masashi 東海大学, 医学部, 教授 (60280947)
• Co-Investigator(Kenkyū-buntansha): SUZUKI Takayoshi 東海大学, 医学部, 准教授 (40287066)
• Project Period (FY): 2010 – 2012
• Keywords: ヘリコバクター・ピロリ / 機能性食品 / 増殖抑制 / IL-8

Research Abstract

Pomegranate juice suppressed growth of all the clinically separated strains of H. pylori and interleukin-8 secretion from stomach cells stimulated by the strains in vitro. As for the germless mice model infected with H. pylori, there were no obvious effects of pomegranate on the bacterial number in the stomach and anti-H. pylori titers in the serum, however, it might strengthen the growth inhibiting action of lactobachilus on H. pylori in the mice model.

Research Products

• [Journal Article] Cranberry extract suppresses interleukin-8 secretion fromstomach cells stimulated by Helicobacter pylori in every clinically separated strain but inhibits growth in part of the strains (2013)
  • Author(s): M Matsushima, T Suzuki, A Masui, T Mine, A Takagi
  • Journal Title: J Funct Foods Volume: 5 Pages: 729-735
  • Peer Reviewed
• [Journal Article] Is it effective? to How to use it?: the era has changed in probiotics and functional food products against Helicobacter pylori infection (2012)
  • Author(s): Matsushima M, Takagi A
  • Journal Title: J Gastroenterol Hepatol Volume: 27(5) Pages: 851-853
  • Peer Reviewed
• [Journal Article] Double-balloon endoscopy versus magnet-imaging enhanced colonosocpy for difficult colonoscopies, a randomized study (2012)
  • Author(s): Suzuki T, Matsushima M, Fujisawa M, Uchida T, Igarashi M, Koike J, Takagi A, Mi ne T
  • Journal Title: Endoscopy Volume: 44 Pages: 38-42
  • Peer Reviewed
• [Journal Article] Effect of pretreatment with Lactobacillus gasseri OLL2716 on first-line Helicobacter pylori eradication therapy (2012)
  • Author(s): Deguchi R, Nakaminami H, Rimbara E, Noguchi N, Sasatsu M, Suzuki T, Matsushima M, Koike J, Igarashi M, Ozawa H, Fukuda R, Takagi A
  • Journal Title: J Gastroeterol Hepatol Volume: 27 Pages: 888-892
  • Peer Reviewed
• [Journal Article] Emergency upper gastrointestinal endoscopy in the emergency room of Tokai University Hospital (2011)
  • Author(s): Matsushima M, Suzuki T, Nakajima T, Arase Y, Tsukune Y, Fujisawa M, Uchida T,Shirakura K, Igarashi M, Koike J, Mine T, Kanari Y, Aoki H
  • Journal Title: Tokai J Exp Clin Med Volume: 36 Pages: 47-52
  • Peer Reviewed
• [Journal Article] 胃潰瘍底が脾動脈に穿破して出血をきたした1 例 (2011)
  • Author(s): 内田哲史,五十嵐宗喜,築根陽子,藤澤美亜,白倉克也,小川真実,小池潤,鈴木孝良,松嶋成志,峯徹哉
  • Journal Title: Progress in Digestive Endoscopy Volume: 79(2) Pages: 64-65
  • Peer Reviewed
• [Journal Article] 保険適応の3 疾患について～ITP～ (2011)
  • Author(s): 鈴木孝良,松嶋成志,高木敦司,峯徹哉
  • Journal Title: Helicobacter Research Volume: 113(1) Pages: 8-10
• [Journal Article] 経過中に腸管嚢腫様気腫を生じた潰瘍性大腸炎の一例 (2011)
  • Author(s): 澤本佳奈,白井孝之,木嶋麻衣子,東徹,築根陽子,大北一郎,渡邊謙一,小池潤,鈴木孝良,松嶋成志,梶原博,峯徹哉
  • Journal Title: Gatroenterological Endoscopy. Volume: 53(5) Pages: 1445-1450
  • Peer Reviewed
• [Journal Article] Gastrointestinal: Colonic Intusscusception to the rectum with sigmoid colon cancer as a lead point (2011)
  • Author(s): Matsushima M, Suzuki T, Sawamoto K, Takagi A, Mine T
  • Journal Title: J Gastroenterol Hepatol Volume: 26 Pages: 414
  • Peer Reviewed
• [Journal Article] バルーン補助法の適応と実際 (2011)
  • Author(s): 鈴木孝良,松嶋成志,中島貴之,藤澤美亜,内田哲史,白倉克也,五十嵐宗喜,小池潤,峯徹哉
  • Journal Title: 消化器内視鏡 Volume: 23(9) Pages: 1525-1529
• [Journal Article] 東南部地区におけるH.pylori感染症治療の現状をみる---東海大学医学部付属病院のH.pylori診断と治療の実際-- (2010)
  • Author(s): 松嶋成志,鈴木孝良,五十嵐宗喜,小池潤,峯徹哉,高木敦司
  • Journal Title: Helicobacter Research Volume: 14(5) Pages: 32-35
• [Journal Article] ダブルバルーン小腸内視鏡が有用であった狭窄型虚血性小腸炎の1例 (2010)
  • Author(s): 齋藤哲彦,鈴木孝良,渡邊謙一,松嶋成志,白井孝之,峯徹哉,平林健一
  • Journal Title: Progress of Digestive Endoscopy Volume: 77 Pages: 104-105
  • Peer Reviewed
• [Journal Article] A case of submucosal hematoma of the esophagus and stomach, possibly caused by fish bone ingestion (2010)
  • Author(s): Koike J, Matsushima M, Teraoka H, Igarashi M, Deguchi R, Suzuki T, Shirai T, Mine T
  • Journal Title: Tokai J Exp Clin Med Volume: 35(1) Pages: 46-56
  • Peer Reviewed
• [Presentation] A case of acute portal vein thrombosis due to chronic relapsing pancreatitis (2012)
  • Author(s): M. Kikuchi, H. Shiozawa, I. Hamada, K. Tsuruya, T. Higashi, J. Aoki, R. Nagashima, J. Koizumi, Y. Arase, K. Shiraishi, Y. Nishizaki, M. Matsushima.
  • Organizer: Asian Pacific Digestive Week 2012
  • Place of Presentation: Bangkok
  • Year and Date: 2012-12-08
• [Presentation] A very rare case of malignant peritoneal mesothelioma presenting umbilical hernia and Sister Mary Joseph's Nodule (2012)
  • Author(s): K. Tsuruya, M. Matsushima, T. Nakajima, M. Fujisawa, T. Uchida, K. Shirakura, M. Igarashi, J. Koike, T. Suzuki, I. Hamada, T. Higashi, M. Kikuchi, H. Shiozawa, J. Aoki, Y. Nishizaki, T. Mine
  • Organizer: Asian Pacific Digestive Week 2012
  • Place of Presentation: Bangkok
  • Year and Date: 2012-12-08
• [Presentation] Is premedication with an anti-cholinergic reagent necessary for transnasal endoscopy? (2012)
  • Author(s): M.Matsushima, T.Suzuki, A.Masui, A.Takagi, T.Mine
  • Organizer: Asian Pacific Digestive Week 2012
  • Place of Presentation: Bangkok
  • Year and Date: 2012-12-06
• [Presentation] クランベリーおよびザクロ果汁の抗ヘリコバクター・ピロリ作用について (2011)
  • Author(s): 松嶋成志,鈴木孝良,峯徹哉
  • Organizer: 第53回日本消化器病学会大会ワークショップ
  • Place of Presentation: 福岡
  • Year and Date: 2011-10-22
• [Presentation] What is the proper screening after H.pylori eradication? (2011)
  • Author(s): Matsushima M, Suzuki T, Koike J, Igarashi M, Mine T, Takagi A
  • Organizer: A proposal from the study on our case of post-HP-eradicated stomach cancer APDW2011
  • Place of Presentation: Singapore
  • Year and Date: 2011-10-02