2012 Fiscal Year Final Research Report
Effect of low-dose aloe emodin on the development of colorectal tumors in Min mice
| Project/Area Number |
22500780
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | Fujita Health University |
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Principal Investigator |
SHIMPO Hiroshi 藤田保健衛生大学, 藤田記念七栗研究所生化学研究部門, 教授 (10142580)
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| Co-Investigator(Renkei-kenkyūsha) |
CHIHARA Takeshi 藤田保健衛生大学, 藤田記念七栗研究所, 講師 (00217241)
KANEKO Takaaki 藤田保健衛生大学, 藤田記念七栗研究所, 助手 (90267956)
TOMATSU Akiko 藤田保健衛生大学, 藤田記念七栗研究所, 技術員 (20440696)
WAKAMATSU Kazumasa 藤田保健衛生大学, 医療科学部, 教授 (80131259)
SHINZATO Masanori 藤田保健衛生大学, 医療科学部, 准教授 (80148288)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 特殊栄養食品 / アロエエモジン / デキストラン硫酸ナトリウム / 潰瘍性大腸炎 / Apc遺伝子変異Minマウス / 大腸腫瘍 |
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| Research Abstract |
Aloe emodin (AE) is a hydroxyanthraquinone compound that is present in some medicinal plants such as Cassia, Rheum, and Aloe. AE has been reported to have anticancer activity in various cancer cell lines and anti-inflammatory effects in murine macrophages. We investigated the cancer chemopreventive effects of low-dose AE on the development of colorectal tumors in ApcMin/+ mice without or with dextran sodium sulfate (DSS). As a result, feeding with low-dose (5, 10 or 50 ppm) AE reduced the development of colorectal tumors in ApcMin/+ mice without or with DSS, although this was not dose-dependent. These results suggest that dietary administration of low-dose (somewhere between 5 and 50 ppm) AE may have chemopreventive effects especially against colitis-related colorectal tumor development in ApcMin/+ mice.
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