2012 Fiscal Year Final Research Report
Vitamin E absorption and effect of food factor on the absorption
| Project/Area Number |
22500782
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | Nagoya University of Arts and Sciences |
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Principal Investigator |
IKEDA Saiko 名古屋学芸大学, 管理栄養学部, 教授 (80308808)
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| Co-Investigator(Kenkyū-buntansha) |
UCHIDA Tomono 愛知学泉大学, 家政学部, 講師 (50440821)
NOMURA Saki 名古屋学芸大学, 管理栄養学部, 助手 (90588956)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 食と栄養 |
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| Research Abstract |
The aim of this study was to evaluate vitamin E catabolism in small intestine and its impact on the tissue distribution of vitamin E metabolites. CEHC was in small intestine of rats after oral administration of vitamin E isoform. We found the catabolic conversion of vitamin E isoform to its metabolite in human intestinal Caco-2 cells. Sesamin, an inhibitor of cytochrome P450-dependent catabolism of vitamin E, increased vitamin E concentration in rat small intestine. Therefore, some dietary vitamin E is likely to be catabolized to CEHC in the small intestine during absorption.
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