2012 Fiscal Year Final Research Report
Involvement of IGF-1 and IGFBPs in nutrition during pregnancy and infancy
| Project/Area Number |
22500791
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | Nakamura Gakuen College |
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Principal Investigator |
UCHIYAMA Fumiaki 中村学園大学, 大学院・栄養科学研究科, 教授 (20389331)
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| Project Period (FY) |
2010 – 2012
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| Keywords | Insulin-like growth factor 1 (IGF-1) / IGF-binding proteins |
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| Research Abstract |
This study investigated the expression profile of IGF-related genes in the liver of female rats with differential food intake with or without Lepidium Meyenii root by using DNA microarray. The expression of IGF-related genes presented in changes within ±50%. Uniquely, there was an 8.5-fold increase in IGFBP-2 mRNA expression. These results show that Lepidium Meyenii root may specifically induce the IGFBP-2 gene expression in rat liver.
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