2012 Fiscal Year Final Research Report
Regulation of Wnt activity by SOX17 in gastrointestinal tumorigenesis
| Project/Area Number |
22500996
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Carcinogenesis
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| Research Institution | Kanazawa University |
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Principal Investigator |
OSHIMA Hiroko 金沢大学, がん進展制御研究所, 助教 (80362515)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 大腸がん / 胃がん / SOX17 / マウスモデル / Wnt |
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| Research Abstract |
Transcription factor SOX17 has shown to function as “tumor promoter” and also “tumor suppressor”, and the role of SOX17 in tumorigenesis has not yet been elucidated. In this project, the role of SOX17 in intestinal tumorigenesis has been examined by genetic studies. Disruption of SOX17 in Apc^Δ716 mouse model resulted in thickened gastric mucosa and significant increase of colonic polyps. These results indicate that SOX17 functions as tumor suppressor in colon cancer development.
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[Journal Article] Inflammation-induced repression of tumor suppressor miR-7 in gastric tumor cells2012
Author(s)
Kong D, Piao YS, Yamashita S, Oshima H, Oguma K, Fushida S, Fujimura T, Minamoto T, Seno H, Yamada Y, Satou K, Ushijima T, Ishikawa T, and Oshima M
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Journal Title
Oncogene
Volume: 31
Pages: 3949-3960
DOI
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[Journal Article] S TAT 3-driven upregulation of TLR2 promotes gastric tumorigenesis independent of tumor inflammation2012
Author(s)
Tye H, Kennedy CL, Najdovska M, McLeod L, McCormach W, Hughes N, Dev A, Sievert W, Ooi CH, Ishikawa TO, Oshima H, Bhathal PS, Parker A, Oshima M, Tan P, and Jenkins B
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Journal Title
Cancer Cell
Volume: 22
Pages: 466-478
DOI
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