2012 Fiscal Year Final Research Report
Development of hereditary non-polyposis colon cancer model using the Mlh1-deficient heterozygous mice
| Project/Area Number |
22501002
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Carcinogenesis
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| Research Institution | National Institute of Radiological Sciences |
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Principal Investigator |
KAKINUMA Shizuko 独立行政法人放射線医学総合研究所, 放射線防護研究センター, チームリーダー (20392219)
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| Co-Investigator(Renkei-kenkyūsha) |
KITO Seiji 独立行政法人放射線医学総合研究所, 放射線防護研究センター, 主任研究員 (20311376)
AMASAKI Yoshiko 独立行政法人放射線医学総合研究所, 放射線防護研究センター, 研究員 (80435700)
MORIOKA Takamitsu 独立行政法人放射線医学総合研究所, 放射線防護研究センター, 研究員 (70253961)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 大腸がん / リンパ腫 / ヘテロ欠失マウス |
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| Research Abstract |
Heterozygous germline mutations of mismatch repair (MMR) genes cause human hereditary non-polyposis colon cancer, and homozygous mutations are manifested by early onset of childhood T- or B-cell leukemia. In order to develop models for both colon cancer and lymphoma, we examined induction protocols with radiation and an inflammatory agent in Mlh1-/- homozygous and Mlh1+/- heterozygous mice. The protocols we established reproducibly induced colon cancer in Mlh1-/- homozygous and Mlh1+/- heterozygous mice, and lymphoma in Mlh1-/- homozygous mice using radiation and/or an inflammatory agent.
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