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2012 Fiscal Year Final Research Report

Identification of microRNA and non-coding RNA regulating the oncogenesis and the progression of colorectal cancers

Research Project

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Project/Area Number 22501015
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Tumor biology
Research InstitutionKyushu University

Principal Investigator

SHIBATA Kohei  九州大学, 大学病院, 准教授 (50363560)

Co-Investigator(Kenkyū-buntansha) MAEDA Toyoki  九州大学, 大学病院, 准教授 (30264112)
Project Period (FY) 2010 – 2012
Keywordsがん遺伝子
Research Abstract

We have focused on novel non-coding RNAs being associated with the oncogenesis and progression of CRC. We applied our established database (aCGH, Gene Expression array, SNP array) to identify the significant molecule by using of the in silico analysis. As a result, we have eventually disclosed three findings;
1) Down-regulation of miR-144 leads to poor prognosis of CRC patients via activation of the mTOR signaling pathway.
2) Expressions of several miRs reflects genomic alterations in colorectal cancer cells. Simultaneous changes of cluster miRs originated form genomic alteration can lead to crucial difference of protein regulation mechanisms continuously, and to influence cancer progression.
3) We demonstrated that G/T rs6983267 allelic variants differently affect lincRNA expression in response to Wnt signaling, and identified MYC as a lincRNA target. Our work suggests a new mechanism for the different CRC risk in subjects carrying the rs6983267 variations.
By grace of the grant, we identified important ncRNA as a candidate clinical marker, and disclosed a new basic oncogenic mechanism in CRC.

  • Research Products

    (39 results)

All 2013 2012 2011 2010

All Journal Article (16 results) Presentation (23 results)

  • [Journal Article] Laparoscopic surgery minimizes the surgical manipulation of isolated tumor cells leading to decreased metastasis compared to open surgery for colorectal cancer2013

    • Author(s)
      Akiyoshi S, Mimori K, Sudo T, Tanaka F, Shibata K, Mori M
    • Journal Title

      Surg Today

      Volume: 43(1) Pages: 20-5

  • [Journal Article] Clinical significance of the expression of long non-coding RNA HOTAIR in primary hepatocellular carcinoma2013

    • Author(s)
      Ishibashi M, Kogo R, Shibata K,Sawada G, Takahashi Y, Kurashige J, Akiyoshi S, Sasaki S, Iwaya T, Sudo T, Sugimachi K, Mimori K, Wakabayashi G, Mori M
    • Journal Title

      Oncol Rep

      Volume: 29(3) Pages: 946-50

  • [Journal Article] Plastin3 is a novel marker for circulating tumor cells undergoing the epithelial-mesenchymal transition and is associated with colorectal cancer prognosis2013

    • Author(s)
      Yokobori T, Iinuma H, Shimamura T, Imoto S, Sugimachi K, Ishii H, Iwatsuki M, Ota D, Ohkuma M, Iwaya T, Nishida N, Kogo R, Sudo T, Tanaka F, Shibata K, Toh H, Sato T, Barnard GF, Fukagawa T, Yamamoto S, Nakanishi H, Sasaki S, Miyano S, Watanabe T, Kuwano
    • Journal Title

      Cancer Res

      Volume: 73(7) Pages: 2059-69

  • [Journal Article] Clinical Significance of PICT1 in Patients of Hepatocellular Carcinoma with Wild-Type TP532013

    • Author(s)
      Ishibashi M, Kogo R, Shibata K, Ueo H, Uchi R, Matsumura T, Takano Y, Sawada G, Takahashi Y, Mima K, Kurashige J, Akiyoshi S, Iwaya T, Eguchi H, Sudo T, Sugimachi K, Suzuki A, Wakabayashi G, Mori M, Mimori K
    • Journal Title

      Ann Surg Oncol

  • [Journal Article] Review: Single nucleotide polymorphisms associated with the oncogenesis of colorectal cancer2012

    • Author(s)
      Mimori K, Tanaka F, Shibata K, Mori M
    • Journal Title

      Surg Today

      Volume: 42(3) Pages: 215-9

  • [Journal Article] Down-regulation of miR-125a-3p in human gastric cancer and its clinicopathological significance2012

    • Author(s)
      Hashiguchi Y, Nishida N, Mimori K, Sudo T, Tanaka F, Shibata K, Ishii H, Mochizuki H, Hase K, Doki Y, Mori M
    • Journal Title

      Int J Oncol

      Volume: 40(5) Pages: 1477-82

  • [Journal Article] MicroRNA-10b is a prognostic indicator in colorectal cancer and confers resistance to the chemotherapeutic agent 5-fluorouracil in colorectal cancer cells2012

    • Author(s)
      Nishida N, Yamashita S, Mimori K, Sudo T, Tanaka F, Shibata K, Yamamoto H, Ishii H, Doki Y, Mori M
    • Journal Title

      Ann Surg Oncol

      Volume: 19(9) Pages: 3065-71

  • [Journal Article] Microarray analysis of colorectal cancer stromal tissue reveals upregulation of two oncogenic miRNA clusters2012

    • Author(s)
      Nishida N, Nagahara M, Sato T, Mimori K, Sudo T, Tanaka F, Shibata K, Ishii H, Sugihara K, Doki Y, Mori M
    • Journal Title

      Clin Cancer Res

      Volume: 18(11) Pages: 3054-70

  • [Journal Article] MicroRNA-372 is associated with poor prognosis in colorectal cancer2012

    • Author(s)
      Yamashita S, Yamamoto H, Mimori K, Nishida N, Takahashi H, Haraguchi N, Tanaka F, Shibata K, Sekimoto M, Ishii H, Doki Y, Mori M
    • Journal Title

      Oncology

      Volume: 82(4) Pages: 205-12

  • [Journal Article] Expression of Mesenchymal Markers Vimentin and Fibronectin: The Clinical Significance in Esophageal Squamous Cell Carcinoma2012

    • Author(s)
      Sudo T, Iwaya T, Nishida N, Sawada G, Takahashi Y, Ishibashi M, Shibata K,Fujita H, Shirouzu K, Mori M, Mimori K
    • Journal Title

      Ann Surg Oncol

  • [Journal Article] Downregulation of miR-144 is associated with colorectal cancer progression via activation of mTOR signaling pathway2012

    • Author(s)
      Iwaya T, Yokobori T, Nishida N, Kogo R, Sudo T, Tanaka F, Shibata K, Sawada G, Takahashi Y, Ishibashi M, Wakabayashi G, Mori M, Mimori K
    • Journal Title

      Carcinogenesis

      Volume: 33(12) Pages: 2391-7

  • [Journal Article] FOXC2 is a novel prognostic factor in human esophageal squamous cell carcinoma2011

    • Author(s)
      Nishida N, Mimori K, Yokobori T, Sudo T, Tanaka F, Shibata K, Ishii H, Doki Y, Mori M
    • Journal Title

      Ann Surg Oncol

      Volume: 18(2) Pages: 535-42

  • [Journal Article] MicroRNA-125a-5p is an independent prognostic factor in gastric cancer and inhibits the proliferation of human gastric cancer cells in combination with trastuzumab2011

    • Author(s)
      Nishida N, Mimori K, Fabbri M, Yokobori T, Sudo T, Tanaka F, Shibata K, Ishii H, Doki Y, Mori M
    • Journal Title

      Clin Cancer Res

      Volume: 17(9) Pages: 2725-33

  • [Journal Article] MicroRNA miR-125b is a prognostic marker in human colorectal cancer2011

    • Author(s)
      Nishida N, Yokobori T, Mimori K, Sudo T, Tanaka F, Shibata K, Ishii H, Doki Y, Kuwano H, Mori M
    • Journal Title

      Int J Oncol

      Volume: 38(5) Pages: 1437-43

  • [Journal Article] Histone deacetylase 1 expression in gastric cancer2011

    • Author(s)
      Sudo T, Mimori K, Nishida N, Kogo R, Iwaya T, Tanaka F, Shibata K, Fujita H, Shirouzu K, Mori M
    • Journal Title

      Oncol Rep

      Volume: 26(4) Pages: 777-82

  • [Journal Article] Long noncoding RNA HOTAIR regulates polycomb-dependent chromatin modification and is associated with poor prognosis in colorectal cancers2011

    • Author(s)
      Kogo R, Shimamura T, Mimori K, Kawahara K, Imoto S, Sudo T, Tanaka F, Shibata K, Suzuki A, Komune S, Miyano S, Mori M
    • Journal Title

      Cancer Res

      Volume: 71(20) Pages: 6320-6

  • [Presentation] 大腸癌におけるゲノムワイド発癌関連多型解析の結果2011

    • Author(s)
      高橋佑典、古後龍之介、西田尚弘、赤木智徳、岩谷岳、主藤朝也、柴田浩平、田中文明、三森功士、森正樹
    • Organizer
      第22回消化器癌発生学会
    • Place of Presentation
      佐賀
    • Year and Date
      20111100
  • [Presentation] HOTAIRは大腸癌においてPRC2を再標的し、予後不良に関わる新規long ncRNAである2011

    • Author(s)
      古後龍之介、島村徹平、三森功士、河原康一、井元清哉、主藤朝也、田中文明、柴田浩平、小宗静男、鈴木聡、森正樹
    • Organizer
      第70回日本癌学会
    • Place of Presentation
      名古屋
    • Year and Date
      20111000
  • [Presentation] 新規癌精巣抗原MCAKからのCTLエピトープの同定とヒト抗腫瘍効果の誘導2011

    • Author(s)
      田中文明、川本恵、主藤朝也、柴田浩平、三森功士、森正樹
    • Organizer
      第70回日本癌学会
    • Place of Presentation
      名古屋
    • Year and Date
      20111000
  • [Presentation] F-boxprotein FBXO31の胃癌における発現低下の重要性2011

    • Author(s)
      主藤朝也、三森功士、西田尚弘、古後龍之介、岩谷岳、田中文明、柴田浩平、藤田博正、白水和雄、森正樹
    • Organizer
      第70回日本癌学会
    • Place of Presentation
      名古屋
    • Year and Date
      20111000
  • [Presentation] 食道扁平上皮癌における17q25.1 TOC locus上の全転写産物解析2011

    • Author(s)
      岩谷岳、三森功士、西田尚弘、古後龍之介、柴田浩平、田中文明、主藤朝也、澤田元太、高橋佑典、石橋正久、森正樹
    • Organizer
      第70回日本癌学会
    • Place of Presentation
      名古屋
    • Year and Date
      20111000
  • [Presentation] 食道癌における転写関連遺伝子FOXC2の臨床病理学的意義2011

    • Author(s)
      西田尚弘、三森功士、澤田元太、高橋佑典、古後龍之介、赤木智徳、岩谷岳、主藤朝也、田中文明、柴田浩平、石井秀始、森正樹
    • Organizer
      第70回日本癌学会
    • Place of Presentation
      名古屋
    • Year and Date
      20111000
  • [Presentation] 個別診療のための大腸発癌および食道発癌ハイリスク因子の同定2011

    • Author(s)
      三森功士、田中文明、主藤朝也、柴田浩平
    • Organizer
      JDDW2011
    • Place of Presentation
      福岡
    • Year and Date
      20111000
  • [Presentation] p53制御遺伝子PICT1の消化器癌における発現解析2011

    • Author(s)
      古後龍之介、河原康一、三森功士、西田尚弘、岩谷岳、石橋正久、高橋佑典、澤田元太、赤木智徳、甲斐裕一郎、主藤朝也、田中文明、柴田浩平、小宗静男、鈴木聡、森正樹
    • Organizer
      第49回日本癌治療学会
    • Place of Presentation
      名古屋
    • Year and Date
      20111000
  • [Presentation] 胃癌におけてHER2を制御するマイクロRMAの検討2011

    • Author(s)
      西田尚弘、三森功士、主藤朝也、田中文明、柴田浩平、石井秀始、森正樹
    • Organizer
      第49回日本癌治療学会
    • Place of Presentation
      名古屋
    • Year and Date
      20111000
  • [Presentation] 早期・進行胃がん症例骨髄のWhole transcriptome 解析による比較検討2011

    • Author(s)
      岩谷岳、深川剛生、三森功士、西田尚弘、古後龍之介、柴田浩平、田中文明、主藤朝也、赤木智徳、高橋佑典、澤田元太、石橋正久、笹子三津留、森正樹
    • Organizer
      第49回日本癌治療学会
    • Place of Presentation
      名古屋
    • Year and Date
      20111000
  • [Presentation] 大腸癌間質におけるマイクロRNA-遺伝子pathwayの包括的解析2011

    • Author(s)
      西田尚弘、永原誠、三森功士、古後龍之介、秋吉清百合、横堀武彦、石丸神矢、石川健二、主藤朝也、田中文明、柴田浩平、森 正 樹
    • Organizer
      第73回大腸癌研究会
    • Place of Presentation
      奄美大島
    • Year and Date
      20110700
  • [Presentation] 大腸癌間質におけるマイクロRNA-遺伝子pathwayの包括的解析2011

    • Author(s)
      岩谷岳、主藤朝也、田中文明、柴田浩平、石井秀始、森正樹
    • Organizer
      第20回日本がん転移学会
    • Place of Presentation
      浜松
    • Year and Date
      20110700
  • [Presentation] 大腸癌におけるmiR-144発現とmTOR制御に関する検討2011

    • Author(s)
      岩谷岳、横堀武彦、三森功士、西田尚弘、古後龍之介、石丸神矢、主藤朝也、田中文明、柴田浩平、森 正 樹
    • Organizer
      第20回日本がん転移学会
    • Place of Presentation
      浜松
    • Year and Date
      20110700
  • [Presentation] SNPにより発現制御を受けるmiRNA,miR-146aの胃癌における解析2011

    • Author(s)
      古後龍之介、三森功士、西田尚弘、岩谷岳、主藤朝也、柴田浩平、田中文明、小宗静男、森正樹
    • Organizer
      第20回日本がん転移学会
    • Place of Presentation
      浜松
    • Year and Date
      20110700
  • [Presentation] 大腸癌細胞における発現およびゲノムCGH プロファイルを用いた8q24多型に関連した癌進展機構の解明2011

    • Author(s)
      三森功士、高角康志、井上裕、岩谷岳、石丸神矢、主藤朝也、田中文明、柴田浩平、杉原健一、森正樹
    • Organizer
      第66回日本消化器外科学会
    • Place of Presentation
      名古屋
    • Year and Date
      20110700
  • [Presentation] 胃癌原発巣・骨髄におけるhistone family 遺伝子発現の検討2011

    • Author(s)
      岩谷岳、三森功士、田中文明、柴田浩平、石丸神矢、西田尚弘、古後龍之介、主藤朝也、若林剛、森正樹
    • Organizer
      第66回日本消化器外科学会
    • Place of Presentation
      名古屋
    • Year and Date
      20110700
  • [Presentation] 副乳頭近傍のIPMNに対して、十二指腸・胆管温存膵頭部切除を施行した1例2011

    • Author(s)
      柴田浩平、西田尚弘、石丸神矢、岩谷岳、主藤朝也、田中文明、三森功士
    • Organizer
      第66回日本消化器外科学会
    • Place of Presentation
      名古屋
    • Year and Date
      20110700
  • [Presentation] 胃癌におけるマイクロRNAmiR-125aの臨床病理学的意義2011

    • Author(s)
      西田尚弘、三森功士、古後龍之介、石丸神矢、岩谷岳、主藤朝也、田中文明、柴田浩平、石井秀始、森正樹
    • Organizer
      第66回日本消化器外科学会
    • Place of Presentation
      名古屋
    • Year and Date
      20110700
  • [Presentation] 新規癌特異遺伝子MCAK癌抗原ペプチド同定と癌特異的免疫治療への応用2011

    • Author(s)
      田中文明、川本恵、主藤朝也、柴田浩平、三森功士、森正樹
    • Organizer
      第32回癌免疫外科研究会
    • Place of Presentation
      和歌山
    • Year and Date
      20110500
  • [Presentation] miR-144によるmTOR制御と大腸癌の予後2011

    • Author(s)
      岩谷岳、横堀武彦、三森功士、主藤朝也、田中文明、柴田浩平、石丸神矢、古後龍之介、西田尚弘、森正樹
    • Organizer
      第111回日本外科学会
    • Place of Presentation
      紙上開催
    • Year and Date
      20110500
  • [Presentation] 大腸癌のゲノムにおけるmicroRNA領域の変異とその臨床学的意義2010

    • Author(s)
      石丸神矢、三森功士、田中文明、柴田浩平、主藤朝也、横堀武彦、西田尚弘、古後龍之介、岩谷岳、杉原健一、森正樹
    • Organizer
      第73回大腸癌研究会
    • Place of Presentation
      奄美大島
    • Year and Date
      20100700
  • [Presentation] 樹状細胞と癌抗原を用いた消化器癌ワクチン治療:癌幹細胞を標的として2010

    • Author(s)
      田中文明、古後龍之介、石川健二、主藤朝也、三森功士、柴田浩平、森正樹
    • Organizer
      第65回日本消化器外科学会
    • Place of Presentation
      下関
    • Year and Date
      20100700
  • [Presentation] 大腸癌間質におけるmicroRNAの発現意義-microRNA arrayと遺伝子発現arrayの統合解析から-2010

    • Author(s)
      西田尚弘、永原誠、三森功士、古後龍之介、横堀武彦、石丸神矢、岩谷岳、主藤朝也、田中文明、柴田浩平、杉原健一、森正樹
    • Organizer
      第19回日本がん転移学会
    • Place of Presentation
      金沢
    • Year and Date
      20100600

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Published: 2014-08-29  

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