2012 Fiscal Year Final Research Report
Analyzing the common mechanism underlying the maintenance of tumorigenity in cancer stem and embryonic stem cells
| Project/Area Number |
22501017
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Tumor biology
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| Research Institution | Saitama Medical University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Keywords | 幹細胞 / UTF1 / ジーンターゲティング |
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| Research Abstract |
UTF1 is expressed not only in embryonic stem cells (ESCs) but also in tumor cells as germ cell tumors. To treat the cancer, it is critical to clarify the mechanism maintaining the tumorigenicity. I previously demonstrated that UTF1 plays an important role to maintain the tumor character in ESCs. Because I hypothesize that the loss of function of UTF1 in ESCs may result in the loss of tumorigenicity, I generated the UTF1 knockout ESCs. Unfortunately, the UTF1 knockout ESCs still maintained the tumorigenicity. This result indicates that the genes in addition to UTF1 may contribute to the tumorigenicity of ESCs.
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