2012 Fiscal Year Final Research Report
The evaluation of suppressive effects concerning tumor metastasisusing soluble VEGF-C receptor
| Project/Area Number |
22501018
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Tumor biology
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KATAGIRI Masato 北里大学, 医療衛生学部, 教授 (50152674)
MAJIMA Masataka 北里大学, 医学部, 教授 (70181641)
MATSUMOTO Kazumasa 北里大学, 医学部, 講師 (70306603)
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| Project Period (FY) |
2010 – 2012
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| Keywords | リンパ管新生 |
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| Research Abstract |
The suppressive effects of lymphangiogenesis using mouse soluble vascular endothelial growth factor (VEGF)-C receptor (sVegfr-2) cDNA introduced mouse embryonic fibroblast cells (C57-sVegfr-2) and Lweis lung carcinoma cells (LLC-sVegfr-2) were evaluated. The production of svegfr-2 and strong binding effect with VEGF-C in the supernatant of C57-sVegfr-2 were verified in vitro by Western blotting and immune -precipitation, respectively. The lymphangiogenesis was significantly reduced in primary lesion, followed by inoculation of LLC-sVegfr-2 into C57 mice, in vivo
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Research Products
(12 results)
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[Journal Article] Thromboxane A(2) receptor signaling facilitates tumor colonization through P-selectin-mediated interaction of tumor cells with platelets and endothelial cells2011
Author(s)
Matsui Y, Amano H, Ito Y 、Eshima K, Suzuki T, Ogawa F, Iyoda A, Satoh Y, Kao S, Nakamura M, Kitasato H, Narumiya S, Majima M
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Journal Title
DOI
Peer Reviewed
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