2012 Fiscal Year Final Research Report
Identification and analysis of novel cancer-cooperating factors using non-biased genome-wide approach
| Project/Area Number |
22501020
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Tumor biology
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| Research Institution | Toho University (2012)
The Institute of Physical and Chemical Research (2010-2011) |
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Principal Investigator |
NAITO Taku 東邦大学, 医学部, 講師 (10568728)
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| Project Period (FY) |
2010 – 2012
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| Keywords | T 細胞分化 / リンパ腫 / エピジェネティクス / 細胞増殖 |
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| Research Abstract |
Mutation of transcription factor causes T-cell lymphoma both in human and mouse. To reveal the molecular mechanism of lymphoma suppression by Ikaros, I determined the gene expression profile, and genome-wide distribution of Ikaros and various histone modifications. A number of Ikaros-target genes were found to have high level of H3K27 tri-methylation (H3K27me3), which abolish in Ikaros knockout cells. T-cell specific erasure of H3K27me3 by Eedknockout resulted in hyper-proliferation of T cells upon mitotic stimulation. Thus, it was strongly suggested that decrease of H3K27me3 at TCR-downstream genes is part of the cause of hyper-proliferation and lymphomagenesis in Ikaros mutant.
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[Journal Article] Harnessing of the Nucleosome Remodeling Deacetylase complex is required for lymphocyte development2012
Author(s)
Zhang J*, Jackson AF*, Naito T*, Seavitt JR, Liu F, Dose F, Kashiwagi M, Yoshida T, Gounari F, Petrie H, Georgopoulos K
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Journal Title
Nature Immunol
Volume: 13
Pages: 86-94
DOI
Peer Reviewed
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[Journal Article] Alternative promoter usage at the Notch1 locus supports ligand-independent signaling in T cell development and leukemogenesis2010
Author(s)
Gomez-del Arco, P., Kashiwagi, M.,*, Jackson, A.F.*, Naito, T.*, Zhang, J., Liu, F., Kee, B., Radtke, F., Redondo, J.M., Georgopoulos, K
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Journal Title
Immunity
Volume: 33
Pages: 685-98
DOI
Peer Reviewed
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