2012 Fiscal Year Final Research Report
Potential role of Mieap, a p53-inducible protein, in tumor suppression and mitochondrial quality control
| Project/Area Number |
22501021
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Tumor biology
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| Research Institution | National Cancer Center Japan |
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Principal Investigator |
NAKAMURA Yasuyuki 独立行政法人国立がん研究センター, 研究所, 研究員 (90569063)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 腫瘍抑制 / p53 / ROS / ミトコンドリア |
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| Research Abstract |
Mieap, a p53-inducible protein, controls mitochondrial quality by repairing or eliminating unhealthy mitochondria via MALM (the Mieap-induced accumulation of lysosome-like organelles within mitochondria: the elimination of oxidized mitochondrial proteins) or MIV (Mieap-induced vacuole: the degradation of unhealthy mitochodria). In human cancer cells, the function is frequently inactivated, leading to the accumulation of unhealthy mitochondria and increase of reactive oxygen species (ROS) production by the mitochondria. The mitochondrial ROS may play a critical role in cancer initiation, progression, invasion and metastasis.
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Research Products
(26 results)
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[Journal Article] Mieap, a p53-inducible protein, controls mitochondrial quality by repairing or eliminating unhealthy mitochondria2011
Author(s)
Kitamura N, Nakamura Y, Miyamoto Y, Miyamoto T, Kabu K, Yoshida M, Futamura M, Ichinose S, Arakawa H
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Journal Title
PLoS One
Volume: 6(1)
Pages: e16060
DOI
Peer Reviewed
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