2012 Fiscal Year Final Research Report
Identification of essential molecules and elucidation of the mechanism for novel cancer immune evasion system: Research for biomarker for immunological response
| Project/Area Number |
22501023
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Tumor immunology
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| Research Institution | Kyushu University |
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Principal Investigator |
OKANO Shinji 九州大学, 大学病院, 臨床助教 (10380429)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 腫瘍免疫 / 免疫回避機構 / バイオマーカー / 癌 |
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| Research Abstract |
We firstly found that a new clone, which have acquired the immune evasion potentials, emerges from the original neoplastic clone, which is susceptible to the tumor associated antigens-specific T cell response. This emergence of neoplastic clone is dependent on the T cell response. The new neoplastic cells have no change in the expression of MHC class I, TRP2, Gp100, IFN-γ (including functional response to IFN-γ), and Fas, but upregulate the expressions of sytl2, GATA1 and 2, and downregulate NGFR, suggesting that the molecules may be potential biomarkers in the immune evasion of neoplasm.
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[Journal Article] 固形腫瘍に対する新規免疫療法の開発当科における第I 相臨床試験の現状-2012
Author(s)
土方 康基, 村橋(伊賀) 睦了,岡崎 利彦, 田中 芳浩, 大平 公亮, 岡野慎士, 久野 晃聖, 高橋 淳, 丸本 朋稔, 井上 博之, 谷 憲三朗
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Journal Title
臨床血液
Volume: 53(5)
Pages: 487-492
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