2012 Fiscal Year Final Research Report
Exploratory research on new tumor markers that are useful for a diagnosis of the early breast cancer and development of a simplified assay system
| Project/Area Number |
22501030
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Tumor diagnosis
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| Research Institution | Osaka University |
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Principal Investigator |
KURONO Sadamu 大阪大学, 大学院・医学系研究科, 招へい准教授 (20271554)
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| Co-Investigator(Kenkyū-buntansha) |
HIEDA Miki 大阪大学, 大学院・医学系研究科, 特任助教 (00380254)
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| Co-Investigator(Renkei-kenkyūsha) |
MATSUURA Shuji 大阪大学, 大学院・医学系研究科, 特任教授 (90142322)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 腫瘍マーカー / プロテオミクス / 乳癌 / 乳頭分泌液 |
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| Research Abstract |
We measured proteome in nipple discharge (ND) and nipple aspirate fluid like (NAF-L), which were collected from breast cancer and non-cancer patients, using two dimensional nano-LC-nanoelectrospray mass spectrometry (ESI-MS), and then 15 kinds of proteins were found as breast cancer candidate markers by various kinds of statistical technique. Furthermore, we have examined the expression of such protein candidate markers using histological stain and ELISA methods for validating as new breast cancer markers.
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[Journal Article] Identification of MIWI-associated Poly(A) RNAs by immunoprecipitation with an anti-MIWI monoclonal antibody.2012
Author(s)
Nishibu, T., Hayashida, Y., Tani, S., Kurono, S., Kojima-Kita, K., Ukekawa, R., Kurokawa, T., Kuramochi-Miyagawa, S., Nakano, T., Inoue, K., and Honda, S.
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Journal Title
Biosci. Trends
Volume: 6
Pages: 248-261
DOI
Peer Reviewed
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[Journal Article] Cell type-dependent gene regulation by Staufen2 in conjunction with Upf1.2011
Author(s)
Miki, T., Kamikawa, Y., Kurono, S., Kaneko, Y., Katahira, J., and Yoneda, Y.
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Journal Title
BMC Mol. Biol.
Volume: 12
Pages: 48
DOI
Peer Reviewed
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[Journal Article] Mechanism for the regulation of mammalian cGMP phosphodiesterase6. 2: Isolation and characterization of the transducin-activated form.2010
Author(s)
Yamazaki, A., Tatsumi, M., Bondarenko, V. A., Kurono, S., Komori, N., Matsumoto, H., Matsuura, I., Hayashi, F., Yamazaki, R. K., and Usukura, J.
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Journal Title
Mol. Cell. Biochem.
Volume: 339
Pages: 235-251
DOI
Peer Reviewed
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[Journal Article] Mechanism for the regulation of mammalian cGMP phosphodiesterase6. 1: Identification of its inhibitory subunit complexes and their roles.2010
Author(s)
Yamazaki, A., Bondarenko, V. A., Matsuura, I., Tatsumi, M., Kurono, S., Komori, N., Matsumoto, H., Hayashi, F., Yamazaki, R. K., and Usukura, J.
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Journal Title
Mol. Cell. Biochem.
Volume: 339
Pages: 215-233
DOI
Peer Reviewed
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