2012 Fiscal Year Final Research Report
Predictive and prognostic significance of tumor-infiltrating lymphocytes in high-grade breast cancer
| Project/Area Number |
22501039
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Tumor diagnosis
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| Research Institution | National Cancer Center Japan |
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Principal Investigator |
TSUDA Hitoshi 独立行政法人国立がん研究センター, 中央病院, 科長 (70217321)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 乳癌 / 腫瘍浸潤リンパ球 / 治療効果予測 / 組織型 |
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| Research Abstract |
The purpose of the present study was to identify histological surrogate predictive markers of pathological complete response (pCR) to neoadjuvant chemotherapy (NAC) in triple-negative breast cancer (TNBC). 92 core needle biopsy (CNB) specimens obtained before NAC were available. As controls, CNB specimens from 42 tumors of the hormone receptor-negative and HER2-positive (HR-/HER2+) subtype and 46 tumors of the hormone receptor-positive and HER2-negative (HR+/HER2-) subtype were also included. Histopathological examination including tumor-infiltrating lymphocytes (TIL) and tumor cell apoptosis, and immunohistochemical studies for basal markers were performed, In TNBC, the pCR rate of tumors showing a high TIL score was 37%, and significantly higher than that of the tumors showing a low TIL score (16%, p = 0.05). In a total of 180 breast cancers, the pCR rate of the tumors showing a high TIL score (34%) was significantly higher than that of the tumors showing a low TIL score (10%) (p = 0.0001). In TNBC, the pCR rate of tumors showing an apoptosis score 2 was 48%, and tended to be higher than that of the tumors showing an apoptosis score of 0 or 1 (23%, p = 0.10). In a total of 180 breast cancers, the pCR rate of the tumors showing an apoptosis score 2 (35%) was significantly higher than that of the tumors showing an apoptosis score of 0 or 1 (19%) (p = 0.04). The basal-like marker expression or p53 nuclear immunoreaction was not correlated with pCR in TNBC. Histologically, medullary/atypical medullary and apocrine types showed higher pCR rates (39% and 40%), while central acellular and metaplastic types showed lower pCR rates (21% and 17%). The degree of TIL correlated with immune response appear to play a substantial role in the response to NAC in TNBC.
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[Journal Article] Tumor-infiltrating lymphocytes (TIL) are correlated with response to neoadjuvant chemotherapy in triple-negative breast cancer.2012
Author(s)
Makiko Ono, Hitoshi Tsuda, Chikako Shimizu, Sohei Yamamoto, Tatsuhiro Shibata, Harukaze Yamamoto, Taizo Hirata, Kan Yonemori, Tsutomu Kouno, Masashi Ando, Kenji Tamura, Noriyuki Katsumata, Takayuki Kinoshita, Yasuhiro Fujiwara
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Journal Title
Breast Cancer Research and Treatment
Volume: 132巻3号
Pages: 793-805
Peer Reviewed
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[Journal Article] Early reduction in standardized uptake value after one cycle of neoadjuvant chemo- therapy measured by sequential DG PET/CT is an independent predictor of patho- logical response of primary breast cancer.2010
Author(s)
Shigeto Ueda, Hitoshi Tsuda, Toshiaki Saeki, Kazuhiko Fukatsu, Akihiko Osaki, Takashi Shigekawa, Jiro Ishida, Katsumi Tamura, Yoshiyuki Abe, Jiro Omata, Tomoyuki Moriya, Junji Yamamoto
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Journal Title
Breast Journal
Volume: 16巻6号
Pages: 660-662
Peer Reviewed
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[Journal Article] Prognostic impact of Ki-67 labeling indices with three different cut-off values and histological and nuclear grades in hormone-receptor- positive, HER2-negative, node-negative invasive breast cancers.
Author(s)
Makiko Ono, Hitoshi Tsuda, Mayu Yunokawa, Kan Yonemori, Chikako Shimizu, Masashi Ando, Kenji Tamura, Takayuki Kinoshita, Yasuhiro Fujiwara
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Journal Title
Breast Cancer
Volume: (in press)
DOI
Peer Reviewed
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