2012 Fiscal Year Final Research Report
Experimental study to develop Src-targeted molecular therapy in small cell lung cancer
| Project/Area Number |
22501044
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Clinical oncology
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| Research Institution | Tottori University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MATSUMOT Shingo 独立行政法人国立がん研究センター, 臨床開発センター, 研究員 (10392341)
HASHIMOTO Kiyoshi 鳥取大学, 医学部附属病院, 助教 (50379640)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 小細胞肺癌 / 分子標的治療 / Src |
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| Research Abstract |
Stem cell factor/c-kit and insulin-like growth factor-I(IGF-I)/IGF-I receptor were detected in small cell lung cancer specimens. In small cell lung cancer cell line, H209 cells, both stem cell factor and IGF-I induced amrubicin resistance. A Src inhibitor, dasatinib, restored the sensitivity to amrubicinin stem cell factor-treated H209 cells. However, dasatinib did not affected IGF-I-induced amrubicinresistance.
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