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2012 Fiscal Year Final Research Report

The study of the development of anti-cancer drug which targets human septin 4 (Bradeion) GTPase

Research Project

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Project/Area Number 22501052
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Clinical oncology
Research InstitutionTokai University

Principal Investigator

TANAKA Tomoo  東海大学, 医学部, 講師 (50192175)

Co-Investigator(Kenkyū-buntansha) KIJIMA Hiroshi  弘前大学, 大学院・医学研究科, 教授 (90204859)
YAMAGUCHI Masamitsu  京都工芸繊維大学, 工芸科学研究科, 教授 (00182460)
TANAKA Manami  独立行政法人産業技術総合研究所, ブラディオン医用機器開発連携研究体, 研究体長 (80188341)
Project Period (FY) 2010 – 2012
Keywords癌 / セプチン / ブラディオン / 腫瘍マーカー医療
Research Abstract

Our research succeeded to provide a practical tool (serum test) to diagnose early stage of cancer such as benign polyps and adenoma, and colonoscopic dissection of these lesions consequently leads to cancer prevention in candidate population. Systematic search for a novel anti-caner drug candidates resulted in more toxicity than efficacy on cancer cells in vitro, and we had to conclude that none of the known candidates could apply in clinics. However, we simultaneously searched and discovered a Chinese compound, Kaiji, which has been introduced to the patients in the NCI Hospital, Ariake, Japan. The limited number of the results showed significant controlling effect on hepatoma and the other adenocarcinoma, by activation of cellular immunity and also by the inhibition of angiogenesis in tumor. We are now applying Kaiji to Drosophila system to show the detailed efficacy on protein-protein and genetic system in cancer cells.

  • Research Products

    (5 results)

All 2012 2011 2010 Other

All Journal Article (1 results) Presentation (3 results) Remarks (1 results)

  • [Journal Article] Bradeion Project: Monitoring and Targeting of Cancer: Molecular Marker Diagnosis of Cancer by Fluorescence Correlation Spectroscopy (FCS)2010

    • Author(s)
      T. Tanaka, Y. Kawamura, Y. Usui, T. Terachi, F. Kimura, T. Asano, M. Hayakawa, N. Sakai, S. Morimoto, Y. Mogi, H. Fujiwara, N. Yamamoto, K, Komori, and M. Tanaka
    • Journal Title

      The Open Conference Proceedings Journal

      Volume: 1 Pages: 129-136

  • [Presentation] Prevention and Early Cure of Colorectal Cancer by Sept4/Bradeion Beta Serum Test2012

    • Author(s)
      T. Tanaka
    • Organizer
      2nd Biomarker Europe Summit
    • Place of Presentation
      Zurich, Switzerland
    • Year and Date
      2012-09-05
  • [Presentation] BRADEION PROJECT: MONITORING AND TARGETING OF CANCER-CHARACTERIZATION OF TISSUE- AND CELL TYPE-SPECIFIC EXPRESSION OF A NOVEL HUMAN SEPTIN FAMILY GENE BARDEION2011

    • Author(s)
      M. Tanaka, H, Kijima, H. Masuda, S. Hori, M. Yamamoto, and T. Tanaka
    • Organizer
      2nd International Conference on Drug Discovery and Therapy., Higher Colleges of Technology and Eureka Science Ltd
    • Place of Presentation
      Dubai, U. A. E.
    • Year and Date
      20110201-04
  • [Presentation] radeion Project: Monitoring and targeting of cancer ---Successful molecular marker diagnosis of cancer by fluorescence correlation spectroscopy (FCS)2011

    • Author(s)
      M. Tanaka, T. Tanaka, F. Kimura, K. Komori, Y. Usui, T. Terachi, N. Yamamoto, S. Morimoto, Y. Sakai, and M. Fujiwara
    • Organizer
      2nd International Conference on Drug Discovery and Therapy, Higher Colleges of Technology and Eureka Science, Ltd
    • Place of Presentation
      Dubai, U. A. E.
    • Year and Date
      2011-02-03
  • [Remarks]

    • URL

      http://www.bradeion.com

URL: 

Published: 2014-08-29   Modified: 2017-10-17  

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