2012 Fiscal Year Final Research Report

Extensive analysis of signaling pathways in breast cancer-proposal of a new classification based on activity of signaling pathways

Research Project

Project/Area Number	22501055
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Clinical oncology
Research Institution	Japanese Foundation For Cancer Research
Principal Investigator	HORII Rie 公益財団法人がん研究会, がん研究所病理部, 研究員 (20446272)
Co-Investigator(Kenkyū-buntansha)	AKIYAMA Futoshi 公益財団法人がん研究会, がん研究所病理部, 臨床病理担当部長 (50222550)
Project Period (FY)	2010 – 2012
Keywords	分子標的治療
Research Abstract	The activation of proliferative signaling pathways is one of the causes of carcinogenesis and several drugs interfering with these pathways are currently being developed. We evaluated 338 invasive breast cancer patients by focusing attention on six factors, p-AKT, Cyclin D1, P27, p-p70S6K, p-4EBP1 and p-MAPK/ERK, in the signaling pathways. These factors were immunohistologically examined and using those results a new breast cancer classification was devised. The new classification was significantly related to conventional clinicopathological characteristics. This classification reflects the activation status of the signaling pathways and useful for selection of newly developed drugs that interfere with signaling pathways