2012 Fiscal Year Final Research Report
Elucidation of interaction between bone marrow micro-metastases in breast cancer patients
| Project/Area Number |
22501056
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Clinical oncology
|
|---|
| Research Institution | Japanese Foundation For Cancer Research |
|---|
Principal Investigator |
TAKAHASHI Syunji 公益財団法人がん研究会, がん化学療法センター臨床部, 研究員 (90221358)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
ITO Yoshinori 公益財団法人がん研究会, がん化学療法センター臨床部, 研究員 (00261131)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Keywords | 乳癌 / 骨転移 / 骨髄微小転移 / 骨微小環境 / ビスホスホネート |
|---|
| Research Abstract |
To elucidate the interaction of disseminated tumor cells in bone marrow (DTC) and bone microenvironment and the effects of bisphosphonates in early breast cancer, we treated breast cancer patients with neoadjuvant chemotherapy with zoledronic acid (ZA), and examined pathological response and changes of DTC, circulating tumor cells (CTC) and circulating endothelial cells (CEC). We treated 30 patients and had Grade 2 to 3 response in 9 patients. CTC was positive in three patients and all became negative after chemotherapy. CEC increased with chemotherapy. Chemotherapy with ZA may increase CEC, and CEC may become a biomarker of neoadjuvant chemotherapy. DTC was positive in only three patients and tumor cells were few, so it was difficult to investigate interaction between tumor cells and cells in bone micro-environment. It should be necessary to investigate interaction between tumor cells and cells in bone micro-environment in the samples of bone metastases
|
-
-
-
[Journal Article] Incidence, risk factors, and outcomes of osteonecrosis of the jaw: integrated analysis from three blinded active-controlled phase III trials in cancer patients with bone metastases2012
Author(s)
Saad F, Brown JE, Van Poznak C, Ibrahim T, Stemmer SM, Stopeck AT, Diel IJ, Takahashi S, Shore N, Henry DH, Barrios CH, Facon T, Senecal F, Fizazi K, Zhou L, Daniels A, Carriere P, Dansey R
-
Journal Title
Ann Oncol
Volume: 23(5)
Pages: 1341-7
-
[Journal Article] Efficacy of zoledronic acid in postmenopausal Japanese women with early breast cancer receiving adjuvant letrozole: 12-month results2012
Author(s)
Takahashi S, Iwase T, Kohno N, Ishikawa T, Taguchi T, Takahashi M, Horiguchi J, Nakamura S, Hozumi Y, Fukunaga M, Noguchi S
-
Journal Title
Breast Cancer Res Treat
Volume: 133(2)
Pages: 685-93
-
[Journal Article] Safety, Efficacy and Pharmacokinetics of Neratinib (HKI-272) in Japanese Patients with Advanced Solid Tumors: A Phase 1 Dose-escalation Study2012
Author(s)
Ito Y, Suenaga M, Hatake K, Takahashi S, Yokoyama M, Onozawa Y, Yamazaki K Hironaka S, Hashigami K, Hasegawa H, Takenaka N, Boku N
-
Journal Title
Jpn J Clin Oncol
Volume: 42(4)
Pages: 278-86
-
-
[Journal Article] Prospective randomized phase II study determines the clinical usefulness of genetic biomarkers for sensitivity to primary chemotherapy with paclitaxel in breast cancer2011
Author(s)
Yoshinori Ito, Koichi Nagasaki, Yoshio Miki, Takuji Iwase, Futoshi Akiyama, Masaaki Matsuura, Rie Horii, Masujiro Makita, Nahomi Tokudome, Masaru Ushijima, Masataka Yoshimoto, Shunji Takahashi, Tetsuo Noda and Kiyohiko Hatake
-
Journal Title
Cancer Sci
Volume: 102(1)
Pages: 130-6
-
-
-
[Journal Article] Bone metastasis and poor performance status are prognostic factors for survival of carcinoma of unknown primary site in patients treated with systematic chemotherapy2010
Author(s)
Kodaira M, Takahashi S, Yamada S, Ueda K, Mishima Y, Takeuchi K, Yamamoto N, Ishikawa Y, Yokoyama M, Saotome T, Terui Y, Hatake K
-
Journal Title
Ann Oncol
Volume: (6)
Pages: 1163-7
-
-
-
[Journal Article] Relationship between bone mineral density and androgen-deprivation therapy in Japanese prostate cancer patients2010
Author(s)
Yuasa T, Maita S, Tsuchiya N, Ma Z, Narita S, Horikawa Y, Yamamoto S, Yonese J, Fukui I, Takahashi S, Hatake K, Habuchi T
-
Journal Title
Urology
Volume: 75(5)
Pages: 1131-7
-
[Journal Article] Bisphosphonate-related osteonecrosis of the jaw: position paper from the Allied Task Force Committee of Japanese Society for Bone and Mineral Research, Japan Osteoporosis Society, Japanese Society of Periodontology, Japanese Society for Oral and Maxillofacial Radiology, and Japanese Society of Oral and Maxillofacial Surgeons2010
Author(s)
Yoneda T, Hagino H, Sugimoto T, Ohta H, Takahashi S, Soen S, Taguchi A, Toyosawa S, Nagata T, Urade M
-
Journal Title
J Bone Miner Metab
Volume: 28(4)
Pages: 365-83
-
-
-
-
-
-
-
-
-
-
-
-
-
