2012 Fiscal Year Final Research Report
Integrative omics study on bone metastatic tumors using clinical samples for clinical applications
| Project/Area Number |
22501057
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Clinical oncology
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| Research Institution | National Cancer Center Japan |
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Principal Investigator |
KONDO Tadashi 独立行政法人国立がん研究センター, 研究所, 分野長 (30284061)
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| Co-Investigator(Kenkyū-buntansha) |
KAWAI Akira 独立行政法人国立がん研究センター, 中央病院, 医長 (90252965)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 化学療法 |
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| Research Abstract |
To reveal the molecular backgrounds of metastatic bone tumor, we created the expression profiles of primary tumor tissues and bone metastatic tissues, which were obtained and storaged at the time of surgery. Lung cancers, breast cancers, hepatocellular carcinomas, colorectal cancers, pancreatic cancers, gastric cancers, renal cell carcinomas, and parotid glad tumors were included this study. Protein expression profiles were created by two-dimensional difference gel electrophoresis, and PROTOMAP. Global microRNA expression was examined by the microarray. We identified genes whose expression levels were aberrantly regulated in the bone-metastatic tumors compared with the primary tumors. The functional significances of the identified genes were verified by the in vitro experiments.
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[Journal Article] Proteomic-based identification of the APC-binding protein EB1 as a candidate of novel tissue biomarker and therapeutic target for colorectal cancer.2012
Author(s)
Sugihara Y, Taniguchi H, Kushima R, Tsuda H, Kubota D, Ichikawa H, Sakamoto K, Nakamura Y, Tomonaga T, Fujita S, Kondo T
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Journal Title
Journal of Proteomics
Volume: 75(17)
Pages: 5342-55
Peer Reviewed
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[Journal Article] Macrophage-capping protein as a tissue biomarker for prediction of response to gemcitabine treatment and prognosis in cholangiocarcinoma.2012
Author(s)
Morofuji N, Ojima H, Onaya H, Okusaka T, Shimada K, Sakamoto Y, Esaki M, Nara S, Kosuge T, Asahina D, Ushigome M, Hiraoka N, Nagino M, Kondo T
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Journal Title
Journal of Proteomics
Volume: 75(5)
Pages: 1577-89
Peer Reviewed
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[Journal Article] Clinical proteomics identified ATP-dependent RNA helicase DDX39 as a novel biomarker to predict poor prognosis of patients with gastrointestinal stromal tumor.2012
Author(s)
Kikuta K, Kubota D, Saito T, Orita H, Yoshida A, Tsuda H, Suehara Y, Katai H, Shimada Y, Toyama Y, Sato K, Kaneko K, Beppu Y, Murakami Y, Kawai A, Kondo T
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Journal Title
Journal of Proteomics
Volume: 75(4)
Pages: 1089-98
Peer Reviewed
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[Journal Article] Pfetin as a prognostic biomarker for gastrointestinal stromal tumor: validation study in multiple clinical facilities.2011
Author(s)
Kubota D, Orita H, Yoshida A, Gotoh M, Kanda T, Tsuda H, Hasegawa T, Katai H, Shimada Y, Kaneko K, Kawai A, Kondo T
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Journal Title
Jpn J Clin Oncol
Volume: 41(10)
Pages: 1194-202
Peer Reviewed
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[Journal Article] Global expression study in colorectal cancer on proteins with alkaline isoelectric point by two-dimensional difference gel electrophoresis.2011
Author(s)
Muto T, Taniguchi H, Kushima R, Tsuda H, Yonemori H, Chen C, Sugihara Y, Sakamoto K, Kobori Y, Palmer H, Nakamura Y, Tomonaga T, Tanaka H, Mizushima H, Fujita S, Kondo T
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Journal Title
Journal of Proteomics
Volume: 74(6)
Pages: 858-73
Peer Reviewed
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[Journal Article] Secernin-1 as a novel prognostic biomarker candidate of synovial sarcoma revealed by proteomics.2011
Author(s)
Suehara Y, Tochigi N, Kubota D, Kikuta K, Nakayama R, Seki K, Yoshida A, Ichikawa H, Hasegawa T, Kaneko K, Chuman H, Beppu Y, Kawai A, Kondo T
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Journal Title
Journal of Proteomics
Volume: 74(6)
Pages: 829-42
Peer Reviewed
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[Journal Article] Peroxiredoxin 2 as a chemotherapy responsiveness biomarker candidate in osteosarcoma revealed by proteomics.2010
Author(s)
Kikuta K, Tochigi N, Saito S, Shimoda T, Morioka H, Toyama Y, Hosono A, Suehara Y, Beppu Y, Kawai A, Hirohashi S, Kondo T
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Journal Title
Proteomics Clinical Applications
Volume: 4(5)
Pages: 560-7
Peer Reviewed
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[Presentation] Proteomic approach for biomarker discovery towards personalized medicine2012
Author(s)
Kondo T, Kubota D, Ichikawa H, Sugihara Y, Sekizaki Y, Murakami Y, Huang C, Fan J, Kawai A
Organizer
Human Proteome Organisation, 11th Annual World Congress
Place of Presentation
Boston, USA
Year and Date
20120909-13
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[Presentation] Biomariker development by sarcoma proteomics2010
Author(s)
Kondo T, Suehara Y, Kikuta K, Kubota D, Hosono A, Yoshida A, Tsuta K, Gotoh M, Hirohashi S, Kawai A
Organizer
16th Annual Connective Tissue Oncology Society Meeting
Place of Presentation
Paris, France
Year and Date
20101111-13
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[Presentation] 蛍光二次元電気泳動法と抗体を用いたプロテオーム解析による大腸がんバイオマーカーの開発2010
Author(s)
近藤 格, 谷口 浩和, 杉原 豊, 陳 臣, 中村 友紀子, 坂本 華乃, 九嶋 亮治, 朝長 毅, 礒辺 俊明, 廣橋 説雄, 藤田 伸
Organizer
第73回大腸癌研究会
Place of Presentation
鹿児島
Year and Date
2010-07-02
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