A double-blind randomization placebo comparison clinical trial was performed using the oral vitamin D supplement for the patient after surgical treatment of lung cancer

2014 Fiscal Year Final Research Report

• Project/Area Number: 22501060
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Cancer epidemiology and prevention
• Research Institution: Jikei University School of Medicine
• Principal Investigator: TADASHI Akiba 東京慈恵会医科大学, 医学部, 教授 (10192907)
• Co-Investigator(Kenkyū-buntansha): URASHIMA Mitsuyoshi 東京慈恵会医科大学, 医学部, 教授 (80203602) ; MORIKAWA Toshiaki 東京慈恵会医科大学, 医学部, 教授 (60292907) ; SATO Shuji 東京慈恵会医科大学, 医学部, 准教授 (80205921) ; ODAKA Makoto 東京慈恵会医科大学, 医学部, 講師 (20233554) ; YAMASHITA Makoto 東京慈恵会医科大学, 医学部, 講師 (10287302)
• Project Period (FY): 2010-04-01 – 2015-03-31
• Keywords: ビタミンDサプリメント / 肺癌

Outline of Final Research Achievements

A double-blind randomization placebo comparison clinical trial was performed using the oral vitamin D supplement for the patient after surgical treatment of lung cancer. Enrolled patient was 202. As for the vitamin D receptor gene analysis, Fok1 was studied in 137 and UGT2B17 in 139. The 25OH vitamin D serum concentration measurement was performed in 157 people. Among them, 36 recurred and 15 were died so far.
More than 18ng/mL 25OHD compared it to under before internal use of supplement, a survival rate was significantly improved as a result of analysis. The death and recurrence rate did not have the significant difference so far between vitamin D group and placebo group.

Free Research Field

胸部外科