2012 Fiscal Year Final Research Report
Investigation on sensitized status to plastic resin materials
| Project/Area Number |
22510036
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Environmental impact assessment/Environmental policy
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| Research Institution | University of Occupational and Environmental Health, Japan |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OYAMA Tsunehiro 産業医科大学, 医学部, 准教授 (00309965)
TANAKA Masayuki 産業医科大学, 医学部, 助教 (80412633)
TSUJI Mayumi 産業医科大学, 医学部, 講師 (40457601)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 健康影響評価 / アレルギー / 樹脂 |
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| Research Abstract |
This study aimed to verify a hypothesis that recent increase of allergy patients is partly explained by antibodies against plastic resin materials. A new method to detect serum antibodies against plastic resin materials were developed by using western-dot blotting. Among 100 wonlen, the positive rates of IgG against phthalic anhydrate and glutaraldehyde were very high. That against toluene 2,4-diisocyanate was around 50%, and those against bisphenol A diglycidyl ether, P-henylenediamine and formaldehyde were very low. The antibody titers against the causal chemical were related to the severity of allergies. From this study, it is suggested that antibodies against plastic resin materials related the onset of allergies.
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Author(s)
Oyama T, Uramoto H, Kagawa N, Yoshimatsu T, Osaki T, Nakanishi R, Nagaya H, Kaneko K, Muto M, Kawamoto T, Tanaka F, Gotoh A
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Journal Title
Frontiers in Bioscience
Volume: S4
Pages: 1539-1546
Peer Reviewed
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Author(s)
Li Q, Kobayashi M, Inagaki H, Hirata Y, Hirata K, Shimizu T, Wang R-S, Suda M, Kawamoto T, Nakajima T, Kawada T
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Journal Title
International Journal of Immunopathology and Pharmacology
Volume: 24
Pages: 837-847
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Author(s)
Kim YD, Eom SY, Zhang YW, Kim H, Park JD, Yu SD, Lee CH, Arashidani K, Kawamoto T, Kim H
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Journal Title
Human Experimental Toxicology
Volume: 30(4)
Pages: 338-342
Peer Reviewed
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[Journal Article] Effects of acetaldehyde inhalation in mitochondrial aldehyde dehaydrogenase deficient mice (Aldh2-/-)2010
Author(s)
Oyama T, Nagayoshi H, Matsuda T, Oka M, Isse T, Yu H-S, Pham TTP, Tanaka M, Kagawa N, Kanako K, Kawamoto T
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Journal Title
Frontiers in Bioscience E
Volume: 2
Pages: 1344-1354
Peer Reviewed
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