2012 Fiscal Year Final Research Report
Novel functions of DNA repair factors: The roles of new XPD complex in the DNA damage responses
| Project/Area Number |
22510061
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | Osaka University |
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Principal Investigator |
SEKI Mineaki 大阪大学, 生命機能研究科, 助教 (40304167)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 修復 / 損傷 / 応答 |
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| Research Abstract |
To understand the mechanisms of genetics disorders caused by compromised nucleotide excision repair system, we started to analyze the roles of novel complex containing XPD in the response to DNA damage. In the course of study, we found another complex functioning in the cytosolic iron-sulfur (Fe-S) cluster assembly pathway. This complex has central roles in the Fe-S cluster assembly in cytosol. Moreover, we also revealed the roles of each component in the complex.
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