2012 Fiscal Year Final Research Report
Why have nematode a radiation tolerance? :Elucidation of the resistant mechanism.
| Project/Area Number |
22510064
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | Tokai University |
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Principal Investigator |
ISHII Naoaki 東海大学, 医学部, 教授 (60096196)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 応答 |
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| Research Abstract |
It is known that nematode shows strong radiation tolerance. In response to harsh environmental conditions, nematode C. elegans larvae undergo dauer stage and recover the normal stage by environmental reform. Modest doses X-irradiation of dauer larvae increased their post-dauer longevity. We founded that the gene expressions of some enzymes of metabolic regulation/anti-oxidation related with metabolic regulation/stress response were up-regulated in the X-ray irradiated dauer larvae. Especially, it is suggested that a transcription factor, mxl-3 plays a role of radiation tolerance
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[Journal Article]2010
Author(s)
Sakashita T, Takanami T, Yanase S, Hamada N, Suzuki M, Kimura T, Kobayashi Y, Ishii N, Higashitani A
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Journal Title
Journal of Radiat. Res.
Volume: 51
Pages: 107-121
DOI
Peer Reviewed
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