2012 Fiscal Year Final Research Report
Reaction Mechanism of new vitamin E analog for protecting radiation injuries
| Project/Area Number |
22510066
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | Nihon Pharmaceutical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MATSUMOTO Kenichiro 放射線医学総合研究所, 重粒子医科学センター, チームリーダー (10297046)
TAKATA Jiro 福岡大学, 薬学部, 教授 (90122704)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 放射線防護剤 / ビタミンE誘導体 / 骨髄死 |
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| Research Abstract |
Several vitamin E analogs were examined against radiation-induced bone marrow death of mice and γ-tocopherol dimethylglycine ester was found to be most effective. It increased the survival of mice after whole body exposure of X-rays or carbon heavy atom radiation. The effect was found to be derived from the increase of the recovery of hematopoietic cells. The compound did not inhibit the control of tumor growth by local carbon heavy atom radiation using mouse xenograft model.
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Research Products
(16 results)
