2012 Fiscal Year Final Research Report
Establishment of assessment system for toxic chemicals based onabnormal protein recognition mechanism in eukaryotic cells.
| Project/Area Number |
22510074
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
TAKADA Koji 東京慈恵会医科大学, 医学部, 准教授 (30179452)
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| Co-Investigator(Kenkyū-buntansha) |
KATO Takashi 早稲田大学, 教育・総合科学学術院 (80350388)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 有害化学物質 / ユビキチン / 異常タンパク質 |
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| Research Abstract |
We focused accumulation of polyubiquitinated proteins in cells which reflect protein abnormality to evaluate chemical-induced toxicity with a new index. By analyzing changes in hardly-soluble polyubiquitin chainsdue to exposure to each test substance using six established cell lines, toxic chemicals could be divided into three groups in terms of their toxic effects on levels of cellular abnormal proteins, which were
(1) increased in all cells
(2) increased in a cell type-dependent manner
(3) unchanged in all cells
The present evaluation system is useful for safety management of chemicals based on the understanding of toxic mechanism.
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Research Products
(14 results)
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[Journal Article] Effects of inorganic mercury on osteoclasts and osteoblasts of the goldfish scales in vitro2011
Author(s)
Suzuki N, Yachiguchi K, Hayakawa K, Omori K, Takada K, Tabata JM, Kitamura K, Endo M, Wada S, Srivastav AK, Chowdhury VS, Oshima Y, Hattori A
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Journal Title
J Fac Agr Kyushu Univ
Volume: 56
Pages: 47-51
URL
Peer Reviewed
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