2012 Fiscal Year Final Research Report
Analysis of Protein adducts derived from environmental carcinogensand their biological activities
| Project/Area Number |
22510076
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | Kanagawa Institute of Technology |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Keywords | 発がん物質 / DNA 付加体 |
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| Research Abstract |
3-nitrobenzanthrone is a newly discovered environmental carcinogen. In this study,in order to know protein modification with NBA, several experiments were performed. NBA was found to modify lysine, cysteine and tryptophan in moderate yields. Chemical structure of lysine modified with NBA was also revealed by the independentchemical synthesis. This material was found in protein hydrolysates that has beentreated with NBA. Howeveri, in vivo formation of this compound was not assigned inthis study.
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