2012 Fiscal Year Final Research Report
Host risk factors for bioaccumulation of oral cadmium in life-stage and lifestyle
| Project/Area Number |
22510077
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | Osaka Ohtani University |
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Principal Investigator |
MIN Kyong-son 大阪大谷大学, 薬学部, 教授 (60140406)
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| Project Period (FY) |
2010 – 2012
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| Keywords | ライフステージ / 経口摂取カドミウム / 必須金属トランスポーター |
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| Research Abstract |
We found some host risk factors for significant increase in bioaccumulation of oral cadmium in life-stage and lifestyle using mice. Pregnancy and lactation increased renal accumulation of oral cadmium in female mice. Moreover, essential metal deficiency such as calcium and iron at a period of growth and vigorous exercise also increased its renal accumulation. An increase in bioaccumulation of oral cadmium may be involved with intestinal expression of essential metal transporters.
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