2012 Fiscal Year Final Research Report
Transgenerational teratogenesis by prenatal exposure to environmental chemicals in mice
| Project/Area Number |
22510078
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | Kinki University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KAGAWA Nao 近畿大学, 理工学部, 講師 (80351568)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 合成エストロゲン / 催奇形性 / 継世代影響 / エピジェネティクス |
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| Research Abstract |
We demonstrated the increased incidence of congenital defects in the offspring of male mice exposed in utero to synthetic estrogens and that the induction of malformations by the estrogens showed a clear threshold effect. Since estrogens have been reported to be non-genotoxic, epigenetic mechanisms may be involved in the transgenerational teratogenesis by estrogen. The expression patterns of Dnmts mRNA, global DNA methylation levels in testicular cells of embryos exposed to estrogen drugs or in sperm of mature male mice exposed prenatally to estrogen drugs were different from those in the controls. These results support that, when evaluating the toxicities of environmental chemicals, epigenetic effects such as DNA methylation should be taken into account.
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