2012 Fiscal Year Final Research Report
Development of microinterface devices for long-term observation of mouse brain
| Project/Area Number |
22510124
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Microdevices/Nanodevices
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| Research Institution | The University of Tokyo |
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Principal Investigator |
ICHIKI Takanori 東京大学, 大学院・工学系研究科, 准教授 (20277362)
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| Project Period (FY) |
2010 – 2012
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| Keywords | マイクロバイオシステム |
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| Research Abstract |
The observation of neural cells in the intact brain of a living animal is one of the most significant challenges in neuroscience. Two-photon laser scanning microscopy (2PLSM) enables the cellular imaging of brain tissue up to a depth of several hundred micrometers and the stimulation of a single synapse of neurons by the photolytic release of caged glutamate, and is thus a powerful tool in neuroscience. However, in the case of observing the intact brain of a living animal, one should drill a hole in the skull and remove the dura to observe deep inside the brain tissue and introduce caged glutamate. Thus, bacterial infection and the loss of brain fluid prevent long-term observation over several weeks. Therefore, we have developed an implantable microscale brain interface device for controlling the concentration of chemicals and enabling the long-term observation of cells in the tissues of living animals by applying microfluidic device technoloy.
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[Presentation] Shape-memory polymer microvalves2012
Author(s)
H. Takehara, K. Uto, M. Ebara, T. Aoyagiand T. Ichiki
Organizer
The 16th Int. Conf. on Miniaturized Systems for Chemistry and Life Sciences (Micro-TAS2012)
Place of Presentation
Okinawa, Japan
Year and Date
20121000
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