2012 Fiscal Year Final Research Report
Study of Microarray Chips to Evaluate Oxidative Stress Induced by Reactive Oxygen Species
| Project/Area Number |
22510125
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Microdevices/Nanodevices
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| Research Institution | Nippon Institute of Technology |
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Principal Investigator |
BAN Masahito 日本工業大学, 工学部, 教授 (70424059)
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| Research Collaborator |
SASAKI Fusako 日本工業大学, 工学研究科, 大学院生
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| Project Period (FY) |
2010 – 2012
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| Keywords | フラーレン / インクジェット / マイクロアレイチップ / 活性酸素 / 酸化ストレス / 細胞毒 |
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| Research Abstract |
The crystalline C_ particleswere three-dimensionally synthesized into m I c r o wells using an ink-jet method, and the PDMS-based microarraychips with reactive oxygenspecies (R O S) generation sources, which generate ROS under visible light irradiation, were fabricated. The cell culture tests using the microarray chips revealed that cytotoxicity induced by ROS was quantitatively evaluated, resulting in creation of the devices to evaluate cellular response to oxidative stress.
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