2012 Fiscal Year Final Research Report
Base excision repair of DNA in chromatin structure
| Project/Area Number |
22510206
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Genome biology
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| Research Institution | Iwate Medical University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Keywords | DNA修復 / クロマチン構造 |
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| Research Abstract |
Genomic DNA is continuously suffered from modification including oxidation and hydrolysis. DNA repair is crucial system for maintaining genetic information, however, chromatin structure is obstacle for repair enzym es to access damage sites. We found a novel protein that interacts with XRCC1, a non-enzymatic DNA repair protein. These proteins localized to insoluble nuclear fraction and critical for chromosomal DNA repair.
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