2012 Fiscal Year Final Research Report
Searching for the causative genes and susceptibility SNPs for diabetes mellitus based on the linkage analysis data
| Project/Area Number |
22510214
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Medical genome science
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| Research Institution | Tokyo Women's Medical University |
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Principal Investigator |
IWASAKI Naoko 東京女子医科大学, 医学部, 准教授 (70203370)
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| Co-Investigator(Kenkyū-buntansha) |
NAKANISHI Toshio 東京女子医科大学, 医学部, 教授 (90120013)
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| Co-Investigator(Renkei-kenkyūsha) |
OGATA Makiko 東京女子医科大学, 医学部, 講師 (10233404)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 2 型糖尿病 / MODY / 創薬 / 次世代シークエンサー / iPS / β細胞 / ミトコンドリア / SNP |
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| Research Abstract |
For type 2 diabetes susceptibility genes, we have identified two genes, LSS and KCNJ15 on chromosome 21, under the peak of LOD curve we had reported. We showed that glucose levels were improved by suppressing the expression of each gene by administration of siRNA in diabetic animal, indicating that LSS and KCNJ15 could be the therapeutic targets for type 2 diabetes. We also found two causative genes by using next generation sequencers in a large MODY family
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