2012 Fiscal Year Final Research Report
Self-assembly of a membrane protein governed by the fluctuation of the anchor peptide and the self-organization.
| Project/Area Number |
22510231
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Living organism molecular science
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| Research Institution | Hiroshima University |
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Principal Investigator |
IZUMI Shunsuke 広島大学, 大学院・理学研究科, 教授 (90203116)
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| Project Period (FY) |
2010 – 2012
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| Keywords | アンカーペプチド / ゆらぎ / 自己組織化 / トポロジー / 膜蛋白質 |
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| Research Abstract |
Information on the fluctuation of protein is important to elucidate the function of the penetration of proteins on the biomembrane.The interaction between phospholipid and melitin molecules as a mode pepetide was evaluated by the mass spectorometery for the liposome. As a result, the relationship between the permeability of melitin through the membrane and the temperature was well fitted by the Arrhenisu law. These experimental results suggest that melitin molecules enhances the instability of the lipid membrane due to the higher permeability which is related to the specific chemical structure.
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