DEVELOPMENT OF NEW FUNCTIONAL MOLECULES BY POLYCYCLIC ALKALOIDS

2012 Fiscal Year Final Research Report

• Project/Area Number: 22510239
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Living organism molecular science
• Research Institution: Hoshi University
• Principal Investigator: MORITA Hiroshi 星薬科大学, 薬学部, 教授 (70220069)
• Project Period (FY): 2010 – 2012
• Keywords: 植物 / 生理活性 / 天然物

Research Abstract

Plants remain to this day one of the most important sources of biological active compounds and continue to provide drug discovery seeds. During our search for active ingredients from medicinal plants, we have isolated anti-malarial polycyclic alkaloids and limonoids with anti-lipid-droplets accumulation activity as new drug discovery seeds and evaluated their activities.

Research Products

• [Journal Article] New Limonoids from Chisocheton ceramicus (2012)
  • Author(s): Wong Chin Piow, Misae Shimada, Alfarius Eko Nugroho, Yusuke Hirasawa, Toshio Kaneda, A. Hamid A. Hadi, Shirota Osamu and Hiroshi Morita, Ceramicines J-L
  • Journal Title: J. Nat. Med. Volume: 66 Pages: 566-570
  • DOI: DOI:10.1007/s11418-011-0616-9
  • Peer Reviewed
• [Journal Article] New Tricyclic Alkaloids, Cassiarins G, H, J, and K from Leaves of Cassia siamea (2012)
  • Author(s): Jun Deguchi, Tomoe Hirahara, Yusuke Hirasawa, Wiwied Ekasari, Aty Widyawaruyanti, Osamu Shirota, Motoo Shiro, and Hiroshi Morita
  • Journal Title: Chem. Pharm. Bull. Volume: 60 Pages: 219-222.
  • DOI: DOI:10.1248/cpb.60.219
  • Peer Reviewed
• [Journal Article] Ceramicines E- I, New Limonoids from Chisocheton ceramicus (2011)
  • Author(s): Wong Chin Piow, Misae Shimada, Yuta Nagakura Alfarius Eko Nugruho, Yusuke Hirasawa, Toshio Kaneda, Khalijah Awang, A. Hamid A. Hadi, Khalit Mohamad, Motoo Shiro, and Hiroshi Morita
  • Journal Title: Chem. Pharm. Bull. Volume: 59 Pages: 407-411.
  • DOI: DOI:10.1248/cpb.59.407
  • Peer Reviewed
• [Journal Article] Total Synthesis of Cassiarin F, A Novel Tetracyclic Alkaloid from the Flowers of Cassia siamea (2011)
  • Author(s): Jun Deguchi, Tomoe Hirahara, Shiori Oshimi, Yusuke Hirasawa, Wiwied Ekasari, Osamu Shirota, Toshio Honda, and Hiroshi Morita
  • Journal Title: Org. Lett. Volume: 13 Pages: 4344-4347
  • DOI: DOI:10.1021/ol201674a
  • Peer Reviewed
• [Journal Article] Ceramicine B, A Limonoid with Anti-Lipid Droplets Accumulation Activity from Chisocheton ceramicus
  • Author(s): Chin Piow Wong, Toshio Kaneda, A. Hamid A. Hadi, and Hiroshi Morita
  • Journal Title: J Nat Med. Volume: (in press)
  • DOI: DOI:10.1007/s11418-013-0755-2
  • Peer Reviewed
• [Presentation] Ceramicines 類の脂肪蓄積抑 制作用とその構造活性相関 (2012)
  • Author(s): Chin Piow Wong, 出口潤 ,Alfarius Eko Nugroho, 平澤祐介 , 金田利夫 ,A. Hamid A. Hadi,森田博史
  • Organizer: 第19回天然薬物の開発と応用シンポジウム
  • Place of Presentation: 大阪
  • Year and Date: 20121101-02
• [Presentation] Cassia siamea および C. spectabilis に含有される抗 マラリア活性 アルカロイドの構造と合成 (2012)
  • Author(s): 出口潤,平原朋恵,石川登希夫,押見史 織 , 平澤祐介 ,本多利雄,代田修, Wiwied Ekasari,森田博史
  • Organizer: 第54回天然有機化合物討論会
  • Place of Presentation: 東京
  • Year and Date: 20120918-19
• [Presentation] Alstonia pneumatophora および A. angustiloba 由来の新規多環性インドールア ルカロイドの構造研究 (2011)
  • Author(s): 小山晃一郎,平澤祐介,金田利夫, Alfarius E. Nugroho ,細谷孝博,在間一将, Teh Chin Hoe , Kit-Lam Chan , 森田博史
  • Organizer: 第53回天然有機化 合物討論会
  • Place of Presentation: 大阪
  • Year and Date: 20110927-29
• [Presentation] マレーシア産 Tabernaemontana dichotoma より単離 したインドールアルカロイドの構造と血管 平滑筋弛緩作用およびラットにおける降圧 作用 (2011)
  • Author(s): 在間一将古賀生美,岩沢信秀,Intan Safinar Ismail,Nordin Hj Lajis,細谷孝 博,平澤祐介,金田利夫,森田博史
  • Organizer: 第53回天然有機化合物討論会
  • Place of Presentation: 大阪
  • Year and Date: 20110927-29
• [Presentation] マレーシア産 Hunteria zeylanica および Leuconotis griffithii より単離した新規インドールアルカロイド の構造と生物活性 (2010)
  • Author(s): Alfarius Eko Nugroho,平澤祐介, 細谷孝博, 在間一将, Khalijah Awang,A. Hamid A. Hadi, 森田博史
  • Organizer: 第52回天然有機化合物討論会
  • Place of Presentation: 静岡
  • Year and Date: 20100929-1001
• [Remarks]
  • URL: http://polaris.hoshi.ac.jp/kyoshitsu/shouyaku/shouyaku.html