2012 Fiscal Year Final Research Report
Development and application of assay systems for searching antipruritic drug.
| Project/Area Number |
22510241
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Living organism molecular science
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| Research Institution | Mukogawa Women's University |
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Principal Investigator |
OKU Hisae 武庫川女子大学, 薬学部, 助教 (90281518)
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| Co-Investigator(Kenkyū-buntansha) |
ISHIGURO Kyoko 武庫川女子大学, 薬学部, 教授 (70151363)
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| Project Period (FY) |
2010 – 2012
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| Keywords | かゆみ治療薬 / アッセイ法 / 天然資源 |
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| Research Abstract |
We established the efficient a model mouse and assay system for searching antipruriticsubstances from natural source for the therapeutic drug of serious itches such as atopicdermatitis. This method monitors the frequency of scratching behavior of the hen egg-whitelysozyme (HEL)-sensitized mouse (= chronic itching model) which exposed restraint stress.HEL-sensitized ddY mouse, in contrast to ddY mouse, have shown worsened the itchiness bystress like humans' atopic dermatitis case. For the search of the protein itch-related factor, weperformed proteome analysis. We screened the antipruritic activity of several natural sourcesand found new seeds and isolated the successively active substance.
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Research Products
(16 results)
