2012 Fiscal Year Final Research Report
Approach toward chemical synthesis of highly branched glycans of glycoconjugate
| Project/Area Number |
22510243
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Living organism molecular science
|
|---|
| Research Institution | The Institute of Physical and Chemical Research |
|---|
Principal Investigator |
ISHIWATA Akihiro 独立行政法人理化学研究所, 伊藤細胞制御化学研究室, 専任研究員 (70342748)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Keywords | 糖鎖合成 / オリゴ糖 / 立体選択的合成 / グリコシル化 / 収斂的合成 / 複合糖質糖鎖 / 多分岐糖鎖 |
|---|
| Research Abstract |
Long-distance intramolecular aglycon delivery (IAD) was conducted to construct 1.2-cis glycosidic linkages whose stereoselective synthesis is one of the most difficult. The convergent strategy toward tetrabranched docosa- and hentriaconta-saccharide arabinan from Mycobacterial arabinan and the strategy for construction of highly branched structure have been studied. IAD method has been improved to achieve the syntheses of core structure of N-glycan and antifreeze glycan fragment from Upis ceramboides. The concentration effect on various factors of accelerated O-glycosylation when the reaction solvent was frozen has been studied.
|
Research Products
(30 results)
